Source:http://linkedlifedata.com/resource/pubmed/id/21064135
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-12-24
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| pubmed:abstractText |
We report the outcome of 236 pediatric umbilical cord blood transplantations (UCBT) performed in Korea. Given that the sources of the grafts were mostly unrelated donors (n = 226; 95.8%), only the results of unrelated UCBT were included for all statistics. The most frequent primary disease was acute leukemia (n = 167). In total, 91.7% of recipients were seropositive for cytomegalovirus (CMV). The median doses of nucleated cells and CD34+ cells were 4.84 × 10(7)/kg and 2.00 × 10(5)/kg, respectively. The median times to neutrophil (>0.5 × 10(9)/L) and platelet recovery (>20 × 10(9)/L) were 18 and 45 days, respectively. Grade 2-4 acute graft-versus-host-disease (GVHD) and chronic GVHD developed in 41.1 and 36.1% of cases, respectively. Forty-five patients developed CMV disease. The 5-year overall and event-free survival were 47.5 and 36.9%, respectively. Multivariate analysis revealed that adverse factors for survival of the whole cohort were total body irradiation-based conditioning (P = 0.007), salvage transplant (P = 0.001), failure to achieve early complete chimerism (P < 0.0005), and CMV disease (P = 0.001). The outcomes of the single- and double-unit UCBT (n = 64) were similar, while double-unit recipients were heavier (P < 0.0005) and older (P < 0.0005). We conclude that double-unit UCBT is a reasonable option for older or heavier children and that the thorough surveillance of CMV infection and the development of an effective CMV therapeutic strategy may be especially important for Korean children, whose CMV seroprevalence exceeds 90%.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1096-8652
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| pubmed:author |
pubmed-author:AhnHyo SeopHS,
pubmed-author:BaekHee JoHJ,
pubmed-author:ChoBinB,
pubmed-author:ChungNak GyunNG,
pubmed-author:HahJeong OkJO,
pubmed-author:HanDong KyunDK,
pubmed-author:HwangTai JuTJ,
pubmed-author:ImHo JoonHJ,
pubmed-author:JungHyun JooHJ,
pubmed-author:KangHyoung JinHJ,
pubmed-author:KimHack KiHK,
pubmed-author:KimSun YoungSY,
pubmed-author:KooHong HoeHH,
pubmed-author:KookHoonH,
pubmed-author:LeeSoo HyunSH,
pubmed-author:LeeYoung HoYH,
pubmed-author:LimYeon JungYJ,
pubmed-author:LimYoung TakYT,
pubmed-author:ParkByung KiuBK,
pubmed-author:ParkHyeon JinHJ,
pubmed-author:ParkJun EunJE,
pubmed-author:ParkSang KyuSK,
pubmed-author:ParkSeong ShikSS,
pubmed-author:RyuKyung HaKH,
pubmed-author:SeoJong JinJJ,
pubmed-author:ShinHee YoungHY,
pubmed-author:SungKi WoongKW,
pubmed-author:YooEun SunES,
pubmed-author:YooKeon HeeKH
|
| pubmed:copyrightInfo |
© 2010 Wiley-Liss, Inc.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
86
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
12-7
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| pubmed:meshHeading |
pubmed-meshheading:21064135-Acute Disease,
pubmed-meshheading:21064135-Adolescent,
pubmed-meshheading:21064135-Child,
pubmed-meshheading:21064135-Child, Preschool,
pubmed-meshheading:21064135-Cord Blood Stem Cell Transplantation,
pubmed-meshheading:21064135-Cytomegalovirus Infections,
pubmed-meshheading:21064135-Disease-Free Survival,
pubmed-meshheading:21064135-Female,
pubmed-meshheading:21064135-Fetal Blood,
pubmed-meshheading:21064135-Graft vs Host Disease,
pubmed-meshheading:21064135-HLA Antigens,
pubmed-meshheading:21064135-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:21064135-Humans,
pubmed-meshheading:21064135-Infant,
pubmed-meshheading:21064135-Infant, Newborn,
pubmed-meshheading:21064135-Leukemia,
pubmed-meshheading:21064135-Male,
pubmed-meshheading:21064135-Multivariate Analysis,
pubmed-meshheading:21064135-Republic of Korea,
pubmed-meshheading:21064135-Retrospective Studies,
pubmed-meshheading:21064135-Treatment Outcome
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| pubmed:year |
2011
|
| pubmed:articleTitle |
Current status of pediatric umbilical cord blood transplantation in Korea: a multicenter retrospective analysis of 236 cases.
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| pubmed:affiliation |
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|