Linked Life Data

21064083

Source:http://linkedlifedata.com/resource/pubmed/id/21064083

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2010-11-10
pubmed:abstractText
There is significant diversity in the TCR repertoire in heterologous and allogeneic immunity. A paper in this issue of the European Journal of Immunology shows that changes in the TCR repertoire can be correlated with outcomes of renal transplantation. This indicates that the diversity of the TCR repertoire could be utilized to monitor clinical phenotypes, such as chronic humoral rejection and operational tolerance in organ transplantation. However, prior to the clinical use of monitoring changes in the TCR repertoire as a biomarker to monitor clinical status after organ transplantation, many questions regarding time dependency, triggering factors and specificity need to be addressed. A causative role for TCR repertoire disruption in organ transplantation will need to be proven by interventional trials that can demonstrate that the TCR repertoire is modifiable and predictive of graft outcome. In this Commentary, we discuss the strengths and opportunities of TCR repertoire monitoring, and point towards yet unanswered questions that will become important if the V? CDR3-length distribution assay will be clinically applied.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1521-4141
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2986-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Harnessing the diversity of the human T-cell repertoire: a monitoring tool for transplantation tolerance?
pubmed:affiliation
Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium. maarten.naesens@uzleuven.be
pubmed:publicationType
Journal Article, Review