Linked Life Data

21064032

Source:http://linkedlifedata.com/resource/pubmed/id/21064032

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-11-24
pubmed:abstractText
Multiple inhibitory receptors may play a role in the weak or absent CD8+ T-cell response in chronic hepatitis B virus (HBV) infection. Yet few receptors have been characterized in detail and little is known about their complex regulation. In the present study, we investigated the role of the signaling lymphocyte activation molecule (SLAM)-related receptor CD244 and of programmed death 1 (PD-1) in HBV infection in 15 acutely and 66 chronically infected patients as well as 9 resolvers and 21 healthy controls. The expression of CD244, PD-1, and T-cell immunoglobulin domain and mucin domain 3 (TIM-3) was analyzed in virus-specific CD8+ T-cells derived from peripheral blood or liver using major histocompatibility complex class I pentamers targeting immunodominant epitopes of HBV, Epstein-Barr-virus (EBV), or influenza virus (Flu). In chronic HBV infection, virus-specific CD8+ T-cells expressed higher levels of CD244 both in the peripheral blood and liver in comparison to the acute phase of infection or following resolution. CD244 was expressed at similarly high levels in EBV infection, but was low on Flu-specific CD8+ T-cells. In chronic HBV infection, high-level CD244 expression coincided with an increased expression of PD-1. The inhibition of the CD244 signaling pathway by antibodies directed against either CD244 or its ligand CD48 resulted in an increased virus-specific proliferation and cytotoxicity as measured by the expression of CD107a, interferon-?, and tumor necrosis factor-? in CD8+ T-cells. Conclusion: CD244 and PD-1 are highly coexpressed on virus-specific CD8+ T-cells in chronic HBV infection and blocking CD244 or its ligand CD48 may restore T-cell function independent of the PD-1 pathway. CD244 may thus be another potential target for immunotherapy in chronic viral infections.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1527-3350
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 American Association for the Study of Liver Diseases.
pubmed:issnType
Electronic
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1934-47
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:21064032-Adult, pubmed-meshheading:21064032-Antigens, CD, pubmed-meshheading:21064032-Apoptosis Regulatory Proteins, pubmed-meshheading:21064032-CD8-Positive T-Lymphocytes, pubmed-meshheading:21064032-Cell Proliferation, pubmed-meshheading:21064032-Epstein-Barr Virus Infections, pubmed-meshheading:21064032-Female, pubmed-meshheading:21064032-HLA-DR Antigens, pubmed-meshheading:21064032-Hepatitis B, Chronic, pubmed-meshheading:21064032-Hepatitis B virus, pubmed-meshheading:21064032-Humans, pubmed-meshheading:21064032-Interferon-gamma, pubmed-meshheading:21064032-Lysosomal-Associated Membrane Protein 1, pubmed-meshheading:21064032-Male, pubmed-meshheading:21064032-Programmed Cell Death 1 Receptor, pubmed-meshheading:21064032-Receptors, Immunologic, pubmed-meshheading:21064032-Tumor Necrosis Factor-alpha, pubmed-meshheading:21064032-Viral Load
pubmed:year
2010
pubmed:articleTitle
The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function.
pubmed:affiliation
Medical Department II and Institute for Immunology, Ludwig-Maximilians-University Munich, Munich, Germany. bijan.raziorrouh@med.uni-muenchen.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't