Source:http://linkedlifedata.com/resource/pubmed/id/21063877
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2011-5-12
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| pubmed:abstractText |
It is almost unknown which demographic factors or medications affect the progression of aortic stenosis (AS) in Japanese patients with mild AS. We identified a total of 194 patients with native tricuspid valvular AS, defined as a continuous-wave Doppler determined peak aortic valve jet velocity of ? 2.0 m/s, in whom echo Doppler studies were repeated at an interim of at least 6 months. Annualized change in peak jet velocity was calculated, and effects of age, sex, diabetes mellitus, blood pressure, serum low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride levels, and use of statins and antihypertensive agents on the progression of AS were retrospectively evaluated. Peak aortic valve jet velocity was 2.36 ± 0.79 m/s (mean ± SD) and annualized increase in peak aortic valve jet velocity was 0.17 ± 0.32 m/s/year for all the studied patients. The increase in peak aortic valve jet velocity was lower in patients taking angiotensin-converting enzyme inhibitors (ACE-Is) than in those not taking ACE-Is (0.04 ± 0.22 vs. 0.20 ± 0.32 m/s/year, P < 0.05). Such protective associations were not observed for other first-line antihypertensive agents and statins. Multiple linear regression analysis revealed that ACE-I treatment, decrease in left ventricular ejection fraction, and higher peak aortic valve jet velocity at the first echocardiogram were associated with slower progression of AS. Administration of ACE-Is was associated with the slow progression of mild AS in Japanese patients. Prospective study to assess this hypothesis is needed.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
|
| pubmed:issn |
1615-2573
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| pubmed:author |
pubmed-author:DaimonTakashiT,
pubmed-author:EzumiAkiraA,
pubmed-author:GodaAkikoA,
pubmed-author:Lee-KawabataMasaakiM,
pubmed-author:MasuyamaTohruT,
pubmed-author:NaitoYoshiroY,
pubmed-author:NakaoShinjiS,
pubmed-author:SakataYasushiY,
pubmed-author:TsujinoTakeshiT,
pubmed-author:WakabayashiKanaK,
pubmed-author:YamamotoKazuhiroK
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
252-7
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| pubmed:meshHeading |
pubmed-meshheading:21063877-Aged,
pubmed-meshheading:21063877-Aged, 80 and over,
pubmed-meshheading:21063877-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:21063877-Aortic Valve,
pubmed-meshheading:21063877-Aortic Valve Stenosis,
pubmed-meshheading:21063877-Asian Continental Ancestry Group,
pubmed-meshheading:21063877-Disease Progression,
pubmed-meshheading:21063877-Echocardiography, Doppler,
pubmed-meshheading:21063877-Female,
pubmed-meshheading:21063877-Humans,
pubmed-meshheading:21063877-Japan,
pubmed-meshheading:21063877-Linear Models,
pubmed-meshheading:21063877-Male,
pubmed-meshheading:21063877-Middle Aged,
pubmed-meshheading:21063877-Retrospective Studies,
pubmed-meshheading:21063877-Severity of Illness Index,
pubmed-meshheading:21063877-Stroke Volume,
pubmed-meshheading:21063877-Time Factors,
pubmed-meshheading:21063877-Treatment Outcome,
pubmed-meshheading:21063877-Ventricular Function, Left
|
| pubmed:year |
2011
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| pubmed:articleTitle |
Administration of angiotensin-converting enzyme inhibitors is associated with slow progression of mild aortic stenosis in Japanese patients.
|
| pubmed:affiliation |
Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, 663-8501, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|