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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1990-4-12
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pubmed:abstractText |
1. The respiratory and psychomotor effects of two benzodiazepines used mainly as anticonvulsants were compared in healthy volunteers, using a double-blind placebo controlled design. 2. Clobazam (10 and 20 mg) produced significantly fewer psychomotor side effects than clonazepam (0.5 and 1 mg). Neither drug at either dose affected the ventilatory response to CO2. 3. Although clonazepam produced significant effects on psychomotor performance, these did not correlate with plasma drug concentration. 4. Our studies provide further evidence that at the doses chosen clobazam is considerably less sedating than clonazepam. Further investigation is required into the tolerance profile of both drugs in patients.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106335-1103919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106335-2862898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106335-3440099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106335-35211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106335-3808299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106335-541390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106335-6032026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106335-6108123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106335-6109011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106335-644547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106335-7107781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2106335-7353567
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
169-77
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2106335-Adult,
pubmed-meshheading:2106335-Anti-Anxiety Agents,
pubmed-meshheading:2106335-Benzodiazepines,
pubmed-meshheading:2106335-Benzodiazepinones,
pubmed-meshheading:2106335-Blood Pressure,
pubmed-meshheading:2106335-Carbon Dioxide,
pubmed-meshheading:2106335-Clonazepam,
pubmed-meshheading:2106335-Double-Blind Method,
pubmed-meshheading:2106335-Flicker Fusion,
pubmed-meshheading:2106335-Humans,
pubmed-meshheading:2106335-Hypnotics and Sedatives,
pubmed-meshheading:2106335-Male,
pubmed-meshheading:2106335-Posture,
pubmed-meshheading:2106335-Psychomotor Performance,
pubmed-meshheading:2106335-Pulse,
pubmed-meshheading:2106335-Reference Values,
pubmed-meshheading:2106335-Respiration
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pubmed:year |
1990
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pubmed:articleTitle |
Respiratory and sedative effects of clobazam and clonazepam in volunteers.
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pubmed:affiliation |
Department of Physiological Sciences, University of Manchester.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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