Linked Life Data

21062313

Source:http://linkedlifedata.com/resource/pubmed/id/21062313

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-11-10
pubmed:abstractText
Koalas (n?=?43) were treated daily for up to 8?weeks with enrofloxacin: 10?mg/kg subcutaneously (s.c.), 5?mg/kg s.c., or 20?mg/kg per os (p.o.); or marbofloxacin: 1.0-3.3?mg/kg p.o., 10?mg/kg p.o. or 5?mg/kg s.c. Serial plasma drug concentrations were determined on day 1 and again at approximately 2?weeks, by liquid chromatography. The median (range) plasma maximum concentrations (C(max) ) for enrofloxacin 5?mg/kg s.c. and 10?mg/kg s.c. were 0.83 (0.68-1.52) and 2.08 (1.34-2.96)??g/mL and the median (range) T(max) were 1.5?h (1-2) and 1?h (1-2) respectively. Plasma concentrations of orally dosed marbofloxacin were too low to be quantified. Oral administration of enrofloxacin suggested absorption rate limited disposition pharmacokinetics; the median (range) C(max) for enrofloxacin 20?mg/kg p.o. was 0.94 (0.76-1.0)??g/mL and the median (range) T(max) was 4?h (2-8). Oral absorption of both drugs was poor. Plasma protein binding for enrofloxacin was 55.4?±?1.9% and marbofloxacin 49.5?±?5.3%. Elevations in creatinine kinase activity were associated with drug injections. Enrofloxacin and marbofloxacin administered at these dosage and routes are unlikely to inhibit the growth of chlamydial pathogens in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1365-2885
pubmed:author
pubmed:copyrightInfo
© 2010 Blackwell Publishing Ltd.
pubmed:issnType
Electronic
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
595-604
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Absorption of enrofloxacin and marbofloxacin after oral and subcutaneous administration in diseased koalas (Phascolarctos cinereus).
pubmed:affiliation
Faculty of Veterinary Science, Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia. joanna.griffith@sydney.edu.au
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't