Linked Life Data

210588

Source:http://linkedlifedata.com/resource/pubmed/id/210588

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1978-10-25
pubmed:abstractText
Sex differences in development of spontaneous liver tumors were studied in mice of CBA strain. Content of mitochondrial proteins, activities of cytochrome oxidase, glucokinase, hexokinase as well as subcellular distribution of hexokinase were also studied in primary hepatomas and in normal liver tissue of the mice of CBA and C3HA strains. Liver tumors occurred in males of CBA strain 7-fold more frequently than in females. Activities of hexokinase, glucokinase, cytochrome oxidase and content of mitochondrial proteins were distinctly alterep both in primary spontaneous hepatomas and in transplantable strains. But, contrary to the transplantable tumors, in spontaneous hepatomas hexokinase, associated with mitochondria, was not found. Decrease in activities of glucokinase and cytochrome oxidase was observed at the early stages of development of CBA strain in males as compared with females of CBA and males of C3HA strains, i.e. distinct decrease in several functional patterns of liver tissue was observed. Subcutaneous administration of orthoamine azotoluene into mice of the C3HA strain caused alteration in activity of these enzymes from liver tissue, which was typical for hepatomas, already at the early steps of development.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0042-8809
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
533-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Biochemical features of the liver of high and low cancer mouse strains and primary spontaneous hepatomas].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract