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rdf:type |
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lifeskim:mentions |
umls-concept:C0006104,
umls-concept:C0026336,
umls-concept:C0035647,
umls-concept:C0040615,
umls-concept:C0205198,
umls-concept:C0205314,
umls-concept:C0220908,
umls-concept:C0243192,
umls-concept:C0439831,
umls-concept:C0441655,
umls-concept:C0597357,
umls-concept:C0679622,
umls-concept:C1415306,
umls-concept:C1879547
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pubmed:issue |
2
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pubmed:dateCreated |
2011-3-1
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pubmed:abstractText |
Schizophrenia is a severe, disabling chronic disorder affecting approximately 1% of the population. Improvements and development of more robust and hopefully predictive screening assays for this disease should enhance the identification and development of novel treatments. The present study describes a rapid and robust method for the testing of potential novel antipsychotics by utilising a simplified [(14)C]2-deoxyglucose (2-DG) autoradiography method following memantine-induced brain activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-aminho-2-thiabicyclo(3.1.0)hexane-...,
http://linkedlifedata.com/resource/pubmed/chemical/Antipsychotic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Bicyclo Compounds, Heterocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic S-Oxides,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyglucose,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Ketamine,
http://linkedlifedata.com/resource/pubmed/chemical/Memantine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/metabotropic glutamate receptor 2,
http://linkedlifedata.com/resource/pubmed/chemical/metabotropic glutamate receptor 3
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1432-2072
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
214
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
505-14
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pubmed:meshHeading |
pubmed-meshheading:21057775-Analysis of Variance,
pubmed-meshheading:21057775-Animals,
pubmed-meshheading:21057775-Antipsychotic Agents,
pubmed-meshheading:21057775-Autoradiography,
pubmed-meshheading:21057775-Bicyclo Compounds, Heterocyclic,
pubmed-meshheading:21057775-Biological Transport,
pubmed-meshheading:21057775-Brain,
pubmed-meshheading:21057775-Carbon Radioisotopes,
pubmed-meshheading:21057775-Cyclic S-Oxides,
pubmed-meshheading:21057775-Deoxyglucose,
pubmed-meshheading:21057775-Disease Models, Animal,
pubmed-meshheading:21057775-Dose-Response Relationship, Drug,
pubmed-meshheading:21057775-Excitatory Amino Acid Agonists,
pubmed-meshheading:21057775-High-Throughput Screening Assays,
pubmed-meshheading:21057775-Ketamine,
pubmed-meshheading:21057775-Male,
pubmed-meshheading:21057775-Memantine,
pubmed-meshheading:21057775-Mice,
pubmed-meshheading:21057775-Mice, Inbred C57BL,
pubmed-meshheading:21057775-Receptors, Metabotropic Glutamate,
pubmed-meshheading:21057775-Reproducibility of Results,
pubmed-meshheading:21057775-Schizophrenia
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pubmed:year |
2011
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pubmed:articleTitle |
Memantine-induced brain activation as a model for the rapid screening of potential novel antipsychotic compounds: exemplified by activity of an mGlu2/3 receptor agonist.
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pubmed:affiliation |
Department of Neuroscience, Janssen Research and Development, Division of Janssen Pharmaceutica NV, Beerse, Belgium. stefanie.dedeurwaerdere@hotmail.com
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pubmed:publicationType |
Journal Article
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