Source:http://linkedlifedata.com/resource/pubmed/id/21056099
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2011-3-22
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pubmed:abstractText |
The annual fish Nothobranchius furzeri is the shortest-lived vertebrate which can be cultured in captivity. Here, we performed a histopathological analysis of age-related lesions in this species. Post-mortem analysis revealed lesions in liver (~90%), kidney (~75%), heart (~70%) and gonads (~40%) which are similar to those previously described in the small teleost Poecilia reticulata. In addition, a high incidence of neoplasias was observed in liver (~35%) and kidney (~25%). Different laboratory strains of N. furzeri show large genetic differences in longevity. Cross-sectional analysis revealed a clear age-dependent increase in the incidence of liver neoplasias which was accelerated in a short-lived strain. Cross-sectional analysis of gonads revealed sex-specific differences in the occurrence of lesions, with males being more severely affected than females. In conclusion, our analysis demonstrates that short life span in N. furzeri is a consequence of a typical teleost aging process which determines systemic failure of homeostasis functions rather than of a single organ or apparatus. Unlike other teleosts, however, this scenario is reinforced by high incidence of age-dependent neoplasias, making this species a promising model to analyze the molecular pathways of age-dependent spontaneous tumorigenesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1873-6815
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pubmed:author | |
pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
249-56
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pubmed:meshHeading |
pubmed-meshheading:21056099-Aging,
pubmed-meshheading:21056099-Animals,
pubmed-meshheading:21056099-Female,
pubmed-meshheading:21056099-Fish Diseases,
pubmed-meshheading:21056099-Gonads,
pubmed-meshheading:21056099-Immunohistochemistry,
pubmed-meshheading:21056099-Killifishes,
pubmed-meshheading:21056099-Liver Neoplasms,
pubmed-meshheading:21056099-Longevity,
pubmed-meshheading:21056099-Male,
pubmed-meshheading:21056099-Neoplasms
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pubmed:year |
2011
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pubmed:articleTitle |
The short-lived annual fish Nothobranchius furzeri shows a typical teleost aging process reinforced by high incidence of age-dependent neoplasias.
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pubmed:affiliation |
Department of Veterinary Sciences, Faculty of Veterinary Medicine, University of Camerino, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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