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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-31
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pubmed:abstractText |
Several small molecule inhibitors of the hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease have advanced successfully to clinical trials. However, the selection of drug-resistant mutants is a significant issue with protease inhibitors (PIs). A variety of amino acid substitutions in the protease domain of NS3 can lead to PI resistance. Many of these significantly impair the replication fitness of HCV RNA replicons. However, it is not known whether these mutations also adversely affect infectious virus assembly and release, processes in which NS3 also participates.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1528-0012
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
140
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
667-75
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:21056040-Amino Acid Substitution,
pubmed-meshheading:21056040-Antiviral Agents,
pubmed-meshheading:21056040-Cell Line,
pubmed-meshheading:21056040-Drug Resistance, Viral,
pubmed-meshheading:21056040-Genetic Fitness,
pubmed-meshheading:21056040-Hepacivirus,
pubmed-meshheading:21056040-Humans,
pubmed-meshheading:21056040-Models, Molecular,
pubmed-meshheading:21056040-Mutation,
pubmed-meshheading:21056040-Protease Inhibitors,
pubmed-meshheading:21056040-Protein Conformation,
pubmed-meshheading:21056040-RNA, Viral,
pubmed-meshheading:21056040-Replicon,
pubmed-meshheading:21056040-Viral Nonstructural Proteins,
pubmed-meshheading:21056040-Virus Replication
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pubmed:year |
2011
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pubmed:articleTitle |
Protease inhibitor-resistant hepatitis C virus mutants with reduced fitness from impaired production of infectious virus.
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pubmed:affiliation |
Division of Infectious Diseases, Department of Medicine, Inflammatory Diseases Institute, and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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