Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-1-17
pubmed:abstractText
We analyzed peripheral blood (PB) and synovial fluid (SF) mononuclear cells from 16 rheumatoid arthritis (RA), 9 spondyloarthritis (SpA), 3 microcrystal arthritis patients, to define the presence of Th17 and Th1 and their relationship with inflammatory activity, and TCR-zeta chain and ZAP-70 levels. Th17 were significantly higher in SF than in PB and more abundant in microcrystal arthritis patients compared to the other groups. Irrespectively of the diagnosis, SF Th17 percentages correlated with joint (SF total leukocyte count, neutrophil percentage) and systemic (C reactive protein [CRP], fibrinogen, erythrocyte sedimentation rate) inflammation markers. SF Th1 percentages directly correlated with inflammation and disease activity (CRP, swollen joint count [SJC]) indices in SpA, but not in RA patients. These observations support the role of Th17 in the pathogenesis of inflammatory arthritides. The TCR-zeta(dim) lymphocytes in SF were found to produce the highest amounts of cytokines including IL-17, whereas no ZAP-70 impairment was associated to Th17.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1521-7035
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
138
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-16
pubmed:meshHeading
pubmed-meshheading:21056009-Adult, pubmed-meshheading:21056009-Aged, pubmed-meshheading:21056009-Aged, 80 and over, pubmed-meshheading:21056009-Arthritis, pubmed-meshheading:21056009-Blood Cells, pubmed-meshheading:21056009-Blood Sedimentation, pubmed-meshheading:21056009-C-Reactive Protein, pubmed-meshheading:21056009-Cell Count, pubmed-meshheading:21056009-Female, pubmed-meshheading:21056009-Fibrinogen, pubmed-meshheading:21056009-Humans, pubmed-meshheading:21056009-Inflammation, pubmed-meshheading:21056009-Interferon-gamma, pubmed-meshheading:21056009-Leukocytes, pubmed-meshheading:21056009-Lymphocyte Activation, pubmed-meshheading:21056009-Lymphocytes, pubmed-meshheading:21056009-Male, pubmed-meshheading:21056009-Middle Aged, pubmed-meshheading:21056009-Monocytes, pubmed-meshheading:21056009-Neutrophils, pubmed-meshheading:21056009-Receptors, Antigen, T-Cell, pubmed-meshheading:21056009-Synovial Fluid, pubmed-meshheading:21056009-Th1 Cells, pubmed-meshheading:21056009-Th17 Cells, pubmed-meshheading:21056009-ZAP-70 Protein-Tyrosine Kinase
pubmed:year
2011
pubmed:articleTitle
Synovial fluid-derived T helper 17 cells correlate with inflammatory activity in arthritis, irrespectively of diagnosis.
pubmed:affiliation
Department of Rheumatology, Catholic University of the Sacred Heart, CIC, Via Moscati 31, 00168, Rome, Italy.
pubmed:publicationType
Journal Article