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rdf:type |
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lifeskim:mentions |
umls-concept:C0002475,
umls-concept:C0011900,
umls-concept:C0017337,
umls-concept:C0020792,
umls-concept:C0205262,
umls-concept:C0205422,
umls-concept:C0238462,
umls-concept:C0241888,
umls-concept:C0439165,
umls-concept:C0543431,
umls-concept:C0694890,
umls-concept:C0813145,
umls-concept:C0919487,
umls-concept:C1518154,
umls-concept:C1704884,
umls-concept:C1709630,
umls-concept:C1742737,
umls-concept:C1833921,
umls-concept:C2347946
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-7
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pubmed:abstractText |
This study was aimed to demonstrate the clinical benefits of rearranged during transfection (RET) genetic screening in patients with apparently sporadic medullary thyroid cancer (MTC) not only to identify the hereditary nature of the disease in the index case but also to discover family members harbouring the same germline mutations (i.e. gene carriers) who are unaware of their condition.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1365-2265
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pubmed:author |
pubmed-author:AgataHH,
pubmed-author:BasoloFF,
pubmed-author:BiaginiAA,
pubmed-author:BotticiVV,
pubmed-author:CosciBB,
pubmed-author:EliseiRR,
pubmed-author:MaterazziGG,
pubmed-author:MolinariCC,
pubmed-author:PassannantiPP,
pubmed-author:PincheraAA,
pubmed-author:RenziniGG,
pubmed-author:RomeoMM,
pubmed-author:UgoliniCC,
pubmed-author:ViolaDD,
pubmed-author:VittiPP
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pubmed:copyrightInfo |
© 2011 Blackwell Publishing Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
241-7
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pubmed:meshHeading |
pubmed-meshheading:21054478-Adolescent,
pubmed-meshheading:21054478-Adult,
pubmed-meshheading:21054478-Aged,
pubmed-meshheading:21054478-Aged, 80 and over,
pubmed-meshheading:21054478-Carcinoma,
pubmed-meshheading:21054478-Female,
pubmed-meshheading:21054478-Genetic Testing,
pubmed-meshheading:21054478-Humans,
pubmed-meshheading:21054478-Male,
pubmed-meshheading:21054478-Middle Aged,
pubmed-meshheading:21054478-Multiple Endocrine Neoplasia Type 2a,
pubmed-meshheading:21054478-Neoplastic Syndromes, Hereditary,
pubmed-meshheading:21054478-Polymerase Chain Reaction,
pubmed-meshheading:21054478-Thyroid Neoplasms,
pubmed-meshheading:21054478-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
RET genetic screening of sporadic medullary thyroid cancer (MTC) allows the preclinical diagnosis of unsuspected gene carriers and the identification of a relevant percentage of hidden familial MTC (FMTC).
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pubmed:affiliation |
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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