Source:http://linkedlifedata.com/resource/pubmed/id/21053877
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2010-11-8
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| pubmed:abstractText |
Few studies emphasize the collagen metabolism-related cytokines and ultrastructure of the completely stress-shielded Achilles tendon. In this study, we used a rat model with complete stress shielding of the Achilles tendon to observe the changes in the ultrastructure of the Achilles tendon and concentration of IL-1 and TGF-? 3 weeks after stress shielding. The model group comprised 12 male Sprague-Dawley rats. The stress of the Achilles tendon of the left hind limb was shielded through tendon cerclage combined with sciatic nerve transection, and the right served as a normal control. Three weeks later, the ultrastructure of the Achilles tendon was observed under electron microscopy and IL-1 and TGF-? levels were determined by enzyme-linked immunosorbent assay. Compared with the control side, collagen fibrils of the shielded Achilles tendons were irregularly arranged and loose. The number of small-diameter collagen fibrils increased significantly with the decrease of the average diameter of collagen fibrils. At the same time, IL-1 concentrations increased significantly in the model group as compared to that in the control group, but no significant difference was found in TGF-? levels. These results suggest that IL-1 may play an important role in the change of ultrastructure after stress shielding.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
1938-2367
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2010, SLACK Incorporated.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
33
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
810
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| pubmed:meshHeading |
pubmed-meshheading:21053877-Achilles Tendon,
pubmed-meshheading:21053877-Animals,
pubmed-meshheading:21053877-Collagen,
pubmed-meshheading:21053877-Contracture,
pubmed-meshheading:21053877-Disease Models, Animal,
pubmed-meshheading:21053877-Fracture Fixation, Internal,
pubmed-meshheading:21053877-Hindlimb,
pubmed-meshheading:21053877-Interleukin-1,
pubmed-meshheading:21053877-Male,
pubmed-meshheading:21053877-Microscopy, Electron, Transmission,
pubmed-meshheading:21053877-Rats,
pubmed-meshheading:21053877-Rats, Sprague-Dawley,
pubmed-meshheading:21053877-Sciatic Nerve,
pubmed-meshheading:21053877-Stress, Mechanical,
pubmed-meshheading:21053877-Suture Techniques,
pubmed-meshheading:21053877-Sutures,
pubmed-meshheading:21053877-Tensile Strength,
pubmed-meshheading:21053877-Transforming Growth Factor beta
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| pubmed:year |
2010
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| pubmed:articleTitle |
Complete stress shielding of the Achilles tendon: ultrastructure and level of interleukin-1 and TGF-?.
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| pubmed:affiliation |
Department of Rehabilitation Medicine, Affiliated Sixth People’s Hospital of Shanghai Jiaotong University, Shanghai, China.
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| pubmed:publicationType |
Journal Article
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