Linked Life Data

21053517

Source:http://linkedlifedata.com/resource/pubmed/id/21053517

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2010-11-5
pubmed:abstractText
The classification of colorectal cancer precursor lesions has become more accurate after the discovery of serrated polyps. These are characterized by saw-tooth-like epithelial growth pattern, and are the most significant group of colorectal cancer precursors after conventional adenomas. While conventional adenomas are characterized by tumour suppressor gene mutations and chromosomal instability, serrated adenomas harbour KRAS/BRAF mutations, inhibition of apoptosis, DNA hypermethylation, and microsatellite instability. These alterations occur in about 20% of colorectal cancers, and along with preserved serrated morphology suggest their origin in serrated polyps. The recognition of serrated polyps as colorectal cancer precursors is crucial for their follow-up.
pubmed:language
fin
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0012-7183
pubmed:author
pubmed:issnType
Print
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2002-11
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
[Colorectal serrated lesions: current insight on their role in colorectal carcinogenesis].
pubmed:affiliation
Oulun yliopisto, diagnostiikan laitos PL 5000, 90014 Oulun yliopisto.
pubmed:publicationType
Journal Article, English Abstract, Review