Source:http://linkedlifedata.com/resource/pubmed/id/21052031
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
2010-12-15
|
pubmed:abstractText |
Angiotensin-converting enzyme inhibitors (ACEi) are the first selected drugs for hypertensive patients because of its protective properties against heart and kidney diseases. Persistent cough is a common adverse reaction associated with ACEi, which can bind to the treatment cessation, but its etiology remains an unresolved issue. The most accepted mechanism is that the inhibition of ACEi increases kinins levels, resulting in the activation of proinflammatory mechanisms and nitric oxide generation. However, relatively little is known about the genetic susceptibility to ACEi-induced cough in hypertensive patients.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
1744-6880
|
pubmed:author | |
pubmed:issnType |
Electronic
|
pubmed:volume |
21
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
10-7
|
pubmed:meshHeading |
pubmed-meshheading:21052031-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:21052031-Case-Control Studies,
pubmed-meshheading:21052031-Cough,
pubmed-meshheading:21052031-Female,
pubmed-meshheading:21052031-Genetic Association Studies,
pubmed-meshheading:21052031-Genetic Predisposition to Disease,
pubmed-meshheading:21052031-Genotype,
pubmed-meshheading:21052031-Humans,
pubmed-meshheading:21052031-Hypertension,
pubmed-meshheading:21052031-Male,
pubmed-meshheading:21052031-Middle Aged,
pubmed-meshheading:21052031-Polymorphism, Single Nucleotide,
pubmed-meshheading:21052031-Retrospective Studies,
pubmed-meshheading:21052031-Risk Factors,
pubmed-meshheading:21052031-Sensitivity and Specificity
|
pubmed:year |
2011
|
pubmed:articleTitle |
Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough.
|
pubmed:affiliation |
Unidad de Hipertensión, Servicio de Medicina Interna, Hospital Universitario de Valme, Carretera de Cádiz S/N bNeocodex, Avda, Charles Darwin, Acc. A. Seville, Spain.
|
pubmed:publicationType |
Journal Article
|