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rdf:type |
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lifeskim:mentions |
umls-concept:C0012798,
umls-concept:C0030705,
umls-concept:C0087111,
umls-concept:C0205245,
umls-concept:C0205419,
umls-concept:C0332281,
umls-concept:C0857121,
umls-concept:C0871261,
umls-concept:C1417660,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
2
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pubmed:dateCreated |
2010-12-30
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pubmed:abstractText |
The capability of the protein NEDD4L to reduce renal tubular expression of epithelial Na+ channel (ENaC) is influenced by a functional rs4149601 G?A NEDD4L polymorphism. As diuretics and ?-blockers inhibit renal sodium reabsorption and renin release, respectively, we hypothesized that the ?-blocker or diuretic-induced blood pressure reduction and prevention of cardiovascular disease would be greater in patients with the highest ENaC expression (rs4149601 G-allele), whereas there would be no such genetically mediated differences in treatment efficacy among patients treated with the vasodilator diltiazem.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1473-5598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
388-95
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pubmed:meshHeading |
pubmed-meshheading:21052022-Adrenergic beta-Antagonists,
pubmed-meshheading:21052022-Aged,
pubmed-meshheading:21052022-Alleles,
pubmed-meshheading:21052022-Antihypertensive Agents,
pubmed-meshheading:21052022-Blood Pressure,
pubmed-meshheading:21052022-Cardiovascular Diseases,
pubmed-meshheading:21052022-Diltiazem,
pubmed-meshheading:21052022-Endosomal Sorting Complexes Required for Transport,
pubmed-meshheading:21052022-Epithelial Sodium Channel,
pubmed-meshheading:21052022-Female,
pubmed-meshheading:21052022-Genotype,
pubmed-meshheading:21052022-Humans,
pubmed-meshheading:21052022-Hypertension,
pubmed-meshheading:21052022-Male,
pubmed-meshheading:21052022-Middle Aged,
pubmed-meshheading:21052022-Polymorphism, Single Nucleotide,
pubmed-meshheading:21052022-Sodium Chloride Symporter Inhibitors,
pubmed-meshheading:21052022-Treatment Outcome,
pubmed-meshheading:21052022-Ubiquitin-Protein Ligases,
pubmed-meshheading:21052022-Vasodilator Agents
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pubmed:year |
2011
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pubmed:articleTitle |
A functional variant of the NEDD4L gene is associated with beneficial treatment response with ?-blockers and diuretics in hypertensive patients.
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pubmed:affiliation |
Department of Clinical Sciences, Lund University and Center for Emergency Medicine, Malmö University Hospital, Malmö, Sweden.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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