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pubmed-article:21051674pubmed:abstractTextAlthough in vitro studies suggest that non-neurogenic regions of the adult central nervous system potentially contain multipotent parenchymal progenitors, neurons are clearly not replaced in most brain regions after injury. Here, in a well-established model of mild transient brain ischemia, we explored Olig2 antagonism and Pax6 overexpression as potential avenues to redirect endogenous progenitors proliferating in situ toward a neuronal fate.lld:pubmed
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pubmed-article:21051674pubmed:articleTitleModulation of fate determinants Olig2 and Pax6 in resident glia evokes spiking neuroblasts in a model of mild brain ischemia.lld:pubmed
pubmed-article:21051674pubmed:affiliationKlinik und Poliklinik für Neurologie, Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. matthias.endres@charite.delld:pubmed
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