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rdf:type |
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lifeskim:mentions |
umls-concept:C0007786,
umls-concept:C0026336,
umls-concept:C0027836,
umls-concept:C0547040,
umls-concept:C0814005,
umls-concept:C1320928,
umls-concept:C1418276,
umls-concept:C1418915,
umls-concept:C1521761,
umls-concept:C1549439,
umls-concept:C1709059,
umls-concept:C2347958
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pubmed:issue |
12
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pubmed:dateCreated |
2010-11-30
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pubmed:abstractText |
Although in vitro studies suggest that non-neurogenic regions of the adult central nervous system potentially contain multipotent parenchymal progenitors, neurons are clearly not replaced in most brain regions after injury. Here, in a well-established model of mild transient brain ischemia, we explored Olig2 antagonism and Pax6 overexpression as potential avenues to redirect endogenous progenitors proliferating in situ toward a neuronal fate.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Basic Helix-Loop-Helix...,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Fibrillary Acidic Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Olig2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/PAX6 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Paired Box Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/doublecortin protein
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1524-4628
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2944-9
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pubmed:meshHeading |
pubmed-meshheading:21051674-Animals,
pubmed-meshheading:21051674-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:21051674-Corpus Striatum,
pubmed-meshheading:21051674-Electrophysiological Phenomena,
pubmed-meshheading:21051674-Eye Proteins,
pubmed-meshheading:21051674-Gene Expression,
pubmed-meshheading:21051674-Glial Fibrillary Acidic Protein,
pubmed-meshheading:21051674-Green Fluorescent Proteins,
pubmed-meshheading:21051674-Homeodomain Proteins,
pubmed-meshheading:21051674-Image Processing, Computer-Assisted,
pubmed-meshheading:21051674-Ischemic Attack, Transient,
pubmed-meshheading:21051674-Membrane Potentials,
pubmed-meshheading:21051674-Mice,
pubmed-meshheading:21051674-Microtubule-Associated Proteins,
pubmed-meshheading:21051674-Nerve Tissue Proteins,
pubmed-meshheading:21051674-Neural Stem Cells,
pubmed-meshheading:21051674-Neuroglia,
pubmed-meshheading:21051674-Neurons,
pubmed-meshheading:21051674-Neuropeptides,
pubmed-meshheading:21051674-Paired Box Transcription Factors,
pubmed-meshheading:21051674-Patch-Clamp Techniques,
pubmed-meshheading:21051674-Phenotype,
pubmed-meshheading:21051674-Repressor Proteins,
pubmed-meshheading:21051674-Retroviridae,
pubmed-meshheading:21051674-Sodium Channels
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pubmed:year |
2010
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pubmed:articleTitle |
Modulation of fate determinants Olig2 and Pax6 in resident glia evokes spiking neuroblasts in a model of mild brain ischemia.
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pubmed:affiliation |
Klinik und Poliklinik für Neurologie, Charité-Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. matthias.endres@charite.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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