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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-28
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pubmed:abstractText |
Tumor protein p53 gene and its negative regulator, murine double minute 2 homolog are important components for cell-cycle arrest and apoptosis. An arginine-to-proline substitution at codon 72 in the p53 gene is reported to decrease apoptotic potential, while a thymine-to-guanine polymorphism at nucleotide 309, named SNP309, of murine double minute 2 gene increases transcription of the gene. These two polymorphisms therefore may be of importance in colorectal carcinogenesis. The relation of these polymorphisms to colorectal cancer risk was addressed in the Fukuoka Colorectal Cancer Study.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1465-3621
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pubmed:author |
pubmed-author:BudhathokiSanjeevS,
pubmed-author:FutamiKitarohK,
pubmed-author:IkejiriKojiK,
pubmed-author:JoshiAmit ManAM,
pubmed-author:KakejiYoshihiroY,
pubmed-author:MaeharaYoshihikoY,
pubmed-author:MaekawaTakafumiT,
pubmed-author:MibuRyuichiR,
pubmed-author:OhnakaKeizoK,
pubmed-author:OkamuraTakeshiT,
pubmed-author:TanakaMasaoM,
pubmed-author:YasunamiYohichiY
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pubmed:issnType |
Electronic
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
232-8
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pubmed:meshHeading |
pubmed-meshheading:21051533-Adult,
pubmed-meshheading:21051533-Aged,
pubmed-meshheading:21051533-Asian Continental Ancestry Group,
pubmed-meshheading:21051533-Case-Control Studies,
pubmed-meshheading:21051533-Colorectal Neoplasms,
pubmed-meshheading:21051533-Female,
pubmed-meshheading:21051533-Genes, p53,
pubmed-meshheading:21051533-Humans,
pubmed-meshheading:21051533-Japan,
pubmed-meshheading:21051533-Logistic Models,
pubmed-meshheading:21051533-Male,
pubmed-meshheading:21051533-Middle Aged,
pubmed-meshheading:21051533-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:21051533-Proto-Oncogene Proteins c-mdm2
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pubmed:year |
2011
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pubmed:articleTitle |
TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study.
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pubmed:affiliation |
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. amitman@phealth.med.kyushu-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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