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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-2-17
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pubmed:abstractText |
Atrial fibrillation (AF) is the most frequent arrhythmia. Screening of SCN5A-the gene encoding the ?-subunit of the cardiac sodium channel-has indicated that disturbances of the sodium current may play a central role in the mechanism of lone AF. We tested the hypothesis that lone AF in young patients is associated with genetic mutations in SCN3B and SCN4B, the genes encoding the two ?-subunits of the cardiac sodium channel.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1755-3245
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pubmed:author |
pubmed-author:ChristiansenMichaelM,
pubmed-author:HaunsøStigS,
pubmed-author:HedleyPaulaP,
pubmed-author:JespersenThomasT,
pubmed-author:LiangBoB,
pubmed-author:MøllerDaniel VDV,
pubmed-author:NielsenJonas BJB,
pubmed-author:OlesenMorten SMS,
pubmed-author:OlesenSøren-PeterSP,
pubmed-author:SchmittNicoleN,
pubmed-author:SvendsenJesper HJH,
pubmed-author:VarróAndrásA
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
786-93
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pubmed:meshHeading |
pubmed-meshheading:21051419-Adolescent,
pubmed-meshheading:21051419-Adult,
pubmed-meshheading:21051419-Atrial Fibrillation,
pubmed-meshheading:21051419-Cohort Studies,
pubmed-meshheading:21051419-Female,
pubmed-meshheading:21051419-Humans,
pubmed-meshheading:21051419-Male,
pubmed-meshheading:21051419-Mutation,
pubmed-meshheading:21051419-Polymerase Chain Reaction,
pubmed-meshheading:21051419-Protein Subunits,
pubmed-meshheading:21051419-Sodium Channels
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pubmed:year |
2011
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pubmed:articleTitle |
Mutations in sodium channel ?-subunit SCN3B are associated with early-onset lone atrial fibrillation.
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pubmed:affiliation |
Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark. morten.salling.olesen@rh.regionh.dk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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