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pubmed-article:21051273pubmed:abstractTextSphingosine 1-phosphate (S1P) is a sphingolipid metabolite, which has emerged as an important signaling mediator participating in the regulation of multiple cellular processes. The discovery of a family of S1P receptors, together with the more recently identified intracellular targets, has provided fundamental understanding of the multi-faceted actions of S1P. Evidence from both in vitro and in vivo studies has implicated the S1P signaling system in the control of immunity, inflammation and many associated diseases. Enigmatically, S1P appears to have both pro- and anti-inflammatory effects depending on the cell context. Here, we review this emerging area and argue for a pivotal role for S1P, as a key mediator of the cytokine network, acting through juxtacrine signaling in the immune system.lld:pubmed
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pubmed-article:21051273pubmed:authorpubmed-author:XiaPuPlld:pubmed
pubmed-article:21051273pubmed:authorpubmed-author:WadhamCarolClld:pubmed
pubmed-article:21051273pubmed:copyrightInfoCrown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:21051273pubmed:year2011lld:pubmed
pubmed-article:21051273pubmed:articleTitleSphingosine 1-phosphate, a key mediator of the cytokine network: juxtacrine signaling.lld:pubmed
pubmed-article:21051273pubmed:affiliationSignal Transduction Program, Centenary Institute and Sydney Medical School University of Sydney, Australia. p.xia@centenary.org.aulld:pubmed
pubmed-article:21051273pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21051273pubmed:publicationTypeReviewlld:pubmed
pubmed-article:21051273pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed