Linked Life Data

21051273

Source:http://linkedlifedata.com/resource/pubmed/id/21051273

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-3-8
pubmed:abstractText
Sphingosine 1-phosphate (S1P) is a sphingolipid metabolite, which has emerged as an important signaling mediator participating in the regulation of multiple cellular processes. The discovery of a family of S1P receptors, together with the more recently identified intracellular targets, has provided fundamental understanding of the multi-faceted actions of S1P. Evidence from both in vitro and in vivo studies has implicated the S1P signaling system in the control of immunity, inflammation and many associated diseases. Enigmatically, S1P appears to have both pro- and anti-inflammatory effects depending on the cell context. Here, we review this emerging area and argue for a pivotal role for S1P, as a key mediator of the cytokine network, acting through juxtacrine signaling in the immune system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1879-0305
pubmed:author
pubmed:copyrightInfo
Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
45-53
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Sphingosine 1-phosphate, a key mediator of the cytokine network: juxtacrine signaling.
pubmed:affiliation
Signal Transduction Program, Centenary Institute and Sydney Medical School University of Sydney, Australia. p.xia@centenary.org.au
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't