Linked Life Data

21051232

Source:http://linkedlifedata.com/resource/pubmed/id/21051232

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2010-11-24
pubmed:abstractText
Osthole, an ingredient of Traditional Chinese Medicine (TCM) from natural product Cnidium monnieri (L.) Cusson, was used as a lead compound for structural modification. A series of osthole derivatives bearing aryl substituents at 3-position of coumarin, has been prepared and evaluated for their growth inhibitory activity against human breast cancer cell lines MCF-7 and MDA-MB-231. Interestingly, some derivatives exhibited good inhibition, among them compound 8e was found to be the most potent compound with IC(50) values of 0.24 ?M, 0.31 ?M against MCF-7 and MDA-MB-231, respectively, which was improved more than 100-folds compared with its parent compound osthole.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1464-3405
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7426-8
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Discovery of novel osthole derivatives as potential anti-breast cancer treatment.
pubmed:affiliation
School of Traditional Chinese Pharmacy, Shanghai University of Traditional Chinese Medicine, Zhangjiang Hi-Tech Park, Shanghai, PR China. youlisha@shutcm.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't