Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-1-13
pubmed:abstractText
Otitis media (OM) is the most prevalent childhood disease in developed countries. Involvement of innate immunity mediated by Toll-like receptors (TLRs) in OM has been implicated primarily in cell lines and by association studies of innate immune gene polymorphisms with OM prevalence. However, the precise role of innate immunity in OM is incompletely understood. We review recent research that has advanced our understanding of how innate immunity in the middle ear is mediated by the interaction of pathogen molecules with receptors such as the TLRs, leading to the activation of adaptor molecules and production of proinflammatory cytokines. TLR genes and signaling molecules are upregulated in OM in a murine model. Deletion of several key innate immune genes results in persistent OM in mice, coupled with an inability to clear bacterial infection from the middle ear. It is concluded that an intact innate immune signaling system is critical to recovery from bacterial OM.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-11163456, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-11359148, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-11438700, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-11642423, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-11905821, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-12488501, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-12524386, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-14561708, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-14993593, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-15226292, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-15231974, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-15241424, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-15459573, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-15485666, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-15567066, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-15626953, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-16237099, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-16303096, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-16893989, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-16944661, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-16954996, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-17097443, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-17142509, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-17154641, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-17266713, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-17318230, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-17721370, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-17908769, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-18049381, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-18164590, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-18272237, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-18354210, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-18986247, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-19120487, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-19586996, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-19966777, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-2000014, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-20164426, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-2478652, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-3731540, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-7995993, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-8174666, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-8808632, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-9237759, http://linkedlifedata.com/resource/pubmed/commentcorrection/21049294-9353016
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1534-6315
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
78-84
pubmed:dateRevised
2011-7-25
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Innate signaling in otitis media: pathogenesis and recovery.
pubmed:affiliation
Department of Otolaryngology, University of Lübeck, Ratzeburger Allee 160, 23564, Lübeck, Germany. anke.leichtle@uk-sh.de
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review
More...