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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1990-2-14
pubmed:abstractText
BALB/c mice infected with Leishmania major develop fatal, progressive disease, despite an immune response characterized by expansion of CD4+ T cells in the draining lymph nodes. The immune response has been further characterized by a lack of IFN-gamma mRNA, but increased IL-4 mRNA in lymphoid tissues, and striking elevation of serum IgE. Treatment of infected BALB/c mice with rIFN-gamma at doses shown to be beneficial in other protozoan infections was insufficient to ameliorate L. major infection. In contrast, neutralization of IL-4 by six weekly injections of mAb 11B11 led to attenuation of disease in 100% of animals, and complete cure in 85%. Resolution of disease required the presence of T cells, and recovered mice remained resistant to reinfection at 12 wk. This immunity was adoptively transferable and was dependent on both CD4+ and CD8+ cells. Although administration of anti-IL-4 was associated with fourfold increase in IFN-gamma mRNA in lymph node cells draining the lesion, the coadministration of neutralizing R4 6A2 anti-IFN-gamma mAb had no effect on resistance to disease. This was in marked contrast to resolution of disease in both resistant C57BL/6- and GK1.5-pretreated BALB/c mice that was abrogated by in vivo treatment with anti-IFN-gamma. These data suggest a novel mechanism of cellular immunity established by interference with the development of Th2 cells during infection.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-2419430, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-2456466, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-2499629, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-2521244, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-2523955, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-2582266, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-2784148, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-2785566, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-2903212, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-2934482, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-2960769, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-2967332, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-3079789, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-3104456, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-3112230, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-3127233, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-3131431, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-3133412, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-3135315, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-3260253, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-3491987, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-3873282, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-3918107, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-3926895, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-398327, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-4504350, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-518835, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-6198115, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-6204550, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-6208278, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-6333458, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-6408190, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-6411853, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-6415111, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-6415170, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-6421982, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-6425450, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-6454739, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-6606002, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-6701528, http://linkedlifedata.com/resource/pubmed/commentcorrection/2104918-7299130
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
171
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
115-27
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism.
pubmed:affiliation
University of California, San Francisco Medical Center, Department of Medicine 94143.
pubmed:publicationType
Journal Article
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