Source:http://linkedlifedata.com/resource/pubmed/id/21048847
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2010-11-4
|
| pubmed:abstractText |
NONUNION FRACTURES AND ASEPTIC BONE NECROSIS ARE TWO PATHOLOGICAL CONDITIONS HAVING SOME IMPAIRMENT OF THE CELLULAR PART OF THE REPAIR: a reduction of MSC and of the osteoblastic activation. Both are good candidates for cell-based therapies using stem cells. We made a review of the published human trials. Only autologous bone marrow aspirate implantation was until now used. In Nonunion, a direct injection-15 to 150?ml-was made in 4 case series studies. In another, the bone marrow aspirate was concentrated before injection. The results were good. In bone necrosis, only one level 1 study was published. The results at 24 months were positive in terms of reduction of the necrosis and appearance of collapse. In 3 case series studies, a treatment with concentrated bone marrow aspirates was deemed useful with good results in 76 to 96%. These results are interesting but need confirmation by controlled studies.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:status |
PubMed-not-MEDLINE
|
| pubmed:issn |
1687-9678
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
2010
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
410170
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Phases 1-3 clinical trials using adult stem cells in osteonecrosis and nonunion fractures.
|
| pubmed:affiliation |
Department of Rheumatology, CHU Sart Tilman, B35, 4000 Liège, Belgium.
|
| pubmed:publicationType |
Journal Article
|