Source:http://linkedlifedata.com/resource/pubmed/id/21048106
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2010-11-18
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| pubmed:abstractText |
Tumor-associated dendritic cells (DCs) often induce T cell anergy or deletion and regulatory T cells instead of antitumor immunity. Although many tumor-associated Ags have been found, there is still no effective vaccine for cancer. Thus, novel rational strategies to enhance the immunogenicity of cancer-specific Ags are needed. Chromosome 1 open reading frame 190 (c1orf190), a gene that encodes a 239-aa hypothetical protein and contains multiple kinase phosphorylation sites, has a wide relationship with multiple signaling pathway molecules and can be regulated by multiple factors, such as TLR ligands. In this study, we demonstrate that c1orf190 can activate NF-?B, drive the production of cytokines, and promote the Ag-presenting function and the priming ability of DCs. Furthermore, c1orf190 can promote resistance of DCs to tumor-associated inhibition not only in the Ag-presenting function but also in the priming ability to induce Ag-specific T lymphocytes. Thus, c1orf190, an NF-?B activator, may be a candidate gene for regulating the function of DCs to resist tumor-associated factor-mediated dysfunction. We also found that c1orf190-mediated cytokine release is achieved by activating the canonical but not the noncanonical NF-?B pathway.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1550-6606
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
1
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| pubmed:volume |
185
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
6719-27
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| pubmed:meshHeading |
pubmed-meshheading:21048106-Amino Acid Sequence,
pubmed-meshheading:21048106-Antigen Presentation,
pubmed-meshheading:21048106-Cell Line,
pubmed-meshheading:21048106-Cells, Cultured,
pubmed-meshheading:21048106-Chromosomes, Human, Pair 1,
pubmed-meshheading:21048106-Coculture Techniques,
pubmed-meshheading:21048106-Cytokines,
pubmed-meshheading:21048106-Dendritic Cells,
pubmed-meshheading:21048106-Dimerization,
pubmed-meshheading:21048106-Female,
pubmed-meshheading:21048106-HeLa Cells,
pubmed-meshheading:21048106-Humans,
pubmed-meshheading:21048106-Immunity, Innate,
pubmed-meshheading:21048106-Inflammation Mediators,
pubmed-meshheading:21048106-Molecular Sequence Data,
pubmed-meshheading:21048106-NF-kappa B,
pubmed-meshheading:21048106-Ovarian Neoplasms,
pubmed-meshheading:21048106-Phosphorylation,
pubmed-meshheading:21048106-Signal Transduction,
pubmed-meshheading:21048106-Trans-Activators,
pubmed-meshheading:21048106-Tumor Suppressor Proteins
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| pubmed:year |
2010
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| pubmed:articleTitle |
Chromosome 1 open reading frame 190 promotes activation of NF-?B canonical pathway and resistance of dendritic cells to tumor-associated inhibition in vitro.
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| pubmed:affiliation |
Department of Immunology, Nankai University School of Medicine and Key Laboratory of Bioactive Materials, Nankai University, Ministry of Education, People's Republic of China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|