Source:http://linkedlifedata.com/resource/pubmed/id/21047203
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2010-11-4
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pubmed:abstractText |
Polymorphisms of genes involved in the pharmacokinetic and pharmacodynamic processes underlie the divergent drug responses among individuals. Despite some successes in identifying these polymorphisms, the candidate gene approach suffers from insufficient gene coverage whereas the genome-wide association approach is limited by less than ideal coverage of SNPs in some important genes. To expand the potential of the candidate approach, we aim to delineate a comprehensive network of drug-response genes for in-depth genetic studies.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1744-8042
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1403-25
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pubmed:meshHeading |
pubmed-meshheading:21047203-Databases, Genetic,
pubmed-meshheading:21047203-Genetic Association Studies,
pubmed-meshheading:21047203-Genetic Variation,
pubmed-meshheading:21047203-Genome-Wide Association Study,
pubmed-meshheading:21047203-Genotype,
pubmed-meshheading:21047203-Humans,
pubmed-meshheading:21047203-MicroRNAs,
pubmed-meshheading:21047203-Pharmaceutical Preparations,
pubmed-meshheading:21047203-Pharmacogenetics,
pubmed-meshheading:21047203-Polymorphism, Single Nucleotide
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pubmed:year |
2010
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pubmed:articleTitle |
Compilation of a comprehensive gene panel for systematic assessment of genes that govern an individual's drug responses.
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pubmed:affiliation |
Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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