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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-11-4
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pubmed:abstractText |
Platinum-based chemoradiotherapy (CRT) as bladder conservation therapy has shown promising results for muscle-invasive bladder cancer. However, treatment-related toxicity remains a major consideration in therapeutic planning. Some common polymorphisms in genes involved in DNA repair (encoding enzymes that repair DNA damaged by platinum agents and ionizing radiation) are reported to result in modulation of the repair capacity. We investigated associations between functional genetic polymorphisms involved in DNA repair and acute toxicity of CRT to determine the predictive value of these polymorphisms for toxicity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1744-8042
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pubmed:author |
pubmed-author:EguchiSatoshiS,
pubmed-author:HaraTakahikoT,
pubmed-author:HaraTomohikoT,
pubmed-author:HinodaYujiY,
pubmed-author:KawaiYoshihisaY,
pubmed-author:MatsumotoHiroakiH,
pubmed-author:MatsuyamaHideyasuH,
pubmed-author:NagaoKazuhiroK,
pubmed-author:NaitoKatsusukeK,
pubmed-author:SakanoShigeruS,
pubmed-author:SasakiMiwaM,
pubmed-author:ShinoharaAsanoA,
pubmed-author:WadaTakashiT
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1377-87
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pubmed:meshHeading |
pubmed-meshheading:21047201-Aged,
pubmed-meshheading:21047201-Aged, 80 and over,
pubmed-meshheading:21047201-Antineoplastic Agents,
pubmed-meshheading:21047201-Cohort Studies,
pubmed-meshheading:21047201-DNA Repair,
pubmed-meshheading:21047201-Female,
pubmed-meshheading:21047201-Genetic Variation,
pubmed-meshheading:21047201-Humans,
pubmed-meshheading:21047201-Male,
pubmed-meshheading:21047201-Middle Aged,
pubmed-meshheading:21047201-Platinum,
pubmed-meshheading:21047201-Polymorphism, Genetic,
pubmed-meshheading:21047201-Predictive Value of Tests,
pubmed-meshheading:21047201-Treatment Outcome,
pubmed-meshheading:21047201-Urinary Bladder Neoplasms
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pubmed:year |
2010
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pubmed:articleTitle |
Nucleotide excision repair gene polymorphisms may predict acute toxicity in patients treated with chemoradiotherapy for bladder cancer.
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pubmed:affiliation |
Department of Urology, Graduate School of Medicine, Yamaguchi University, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan. shigerus@yamaguchi-u.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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