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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-12-30
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pubmed:abstractText |
Spontaneously hypertensive rats (SHRs) are characterized by capillary rarefaction, which may contribute to blood pressure elevation. We hypothesized that capillary rarefaction involves a suppressed angiogenesis; renin inhibition influences anti-angiogenesis homeostasis by acting on angiopoietins; transient renin blockade reduces anti-angiogenesis thereby ameliorating long-lasting blood pressure and cardiac hypertrophy in SHRs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1473-5598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
266-72
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pubmed:dateRevised |
2011-8-3
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pubmed:meshHeading |
pubmed-meshheading:21045736-Amides,
pubmed-meshheading:21045736-Angiopoietin-1,
pubmed-meshheading:21045736-Angiopoietin-2,
pubmed-meshheading:21045736-Animals,
pubmed-meshheading:21045736-Antihypertensive Agents,
pubmed-meshheading:21045736-Blood Pressure,
pubmed-meshheading:21045736-Capillaries,
pubmed-meshheading:21045736-Fumarates,
pubmed-meshheading:21045736-Hypertension,
pubmed-meshheading:21045736-Male,
pubmed-meshheading:21045736-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:21045736-Neovascularization, Physiologic,
pubmed-meshheading:21045736-Rats,
pubmed-meshheading:21045736-Rats, Inbred SHR,
pubmed-meshheading:21045736-Rats, Inbred WKY,
pubmed-meshheading:21045736-Renin,
pubmed-meshheading:21045736-Signal Transduction,
pubmed-meshheading:21045736-Ventricular Remodeling
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pubmed:year |
2011
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pubmed:articleTitle |
Renin inhibition mitigates anti-angiogenesis in spontaneously hypertensive rats.
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pubmed:affiliation |
Department of Nephrology, Klinikum rechts der Isar, Technical University Munich, Germany.
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pubmed:publicationType |
Journal Article
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