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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-1-7
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pubmed:abstractText |
Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic involvement. The susceptibility genes identified so far can only explain a small proportion of disease heritability. Through a genome-wide association in a Hong Kong Chinese cohort and subsequent replication in two other Asian populations, with a total of 3164 patients and 4482 matched controls, we identified association of ELF1 (E74-like factor 1) with SLE (rs7329174, OR = 1.26, joint P= 1.47 × 10(-8)). ELF1 belongs to the ETS family of transcription factors and is known to be involved in T cell development and function. Database analysis revealed transcripts making use of three alternative exon1s for this gene. Near equivalent expression levels of distinct transcripts initiated from alternative exon1s were detected in peripheral blood mononuclear cells from both SLE patients and healthy controls. Although a direct association of rs7329174 with the three forms of transcripts for this gene was not detected, these findings support an important role of ELF1 in SLE susceptibility and suggest a potentially tight regulation for the expression of this gene.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1460-2083
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pubmed:author |
pubmed-author:AvihingsanonYingyosY,
pubmed-author:BaumLarryL,
pubmed-author:ChanTak MaoTM,
pubmed-author:ChernyStacey SSS,
pubmed-author:DeekajorndejThavatchaiT,
pubmed-author:Garcia-BarcelóMaria-MercèMM,
pubmed-author:HirankarnNattiyaN,
pubmed-author:HoMarco Hok KungMH,
pubmed-author:KwanPatrickP,
pubmed-author:LauChak SingCS,
pubmed-author:LauYu LungYL,
pubmed-author:LeeKa WingKW,
pubmed-author:LeePamela Pui WahPP,
pubmed-author:LeeTsz LeungTL,
pubmed-author:LeungAlexander Moon HoAM,
pubmed-author:LiXiang-PeiXP,
pubmed-author:MokChi ChiuCC,
pubmed-author:MokMo YinMY,
pubmed-author:NgIrene Oi LinIO,
pubmed-author:PanHai-FengHF,
pubmed-author:RianthavornPornpimolP,
pubmed-author:ShamPak ChungPC,
pubmed-author:ShotelersukVorasukV,
pubmed-author:SuphapeetipornKanyaK,
pubmed-author:TamPaul Kwong-HangPK,
pubmed-author:WongChun-MingCM,
pubmed-author:WongRaymond Woon SingRW,
pubmed-author:WongSik NinSN,
pubmed-author:WongWilfred Hing SangWH,
pubmed-author:YangJingJ,
pubmed-author:YangWanlingW,
pubmed-author:YeDong QingDQ,
pubmed-author:ZengShuaiS,
pubmed-author:ZhangJingJ,
pubmed-author:ZhangYanY
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
601-7
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pubmed:meshHeading |
pubmed-meshheading:21044949-Asian Continental Ancestry Group,
pubmed-meshheading:21044949-China,
pubmed-meshheading:21044949-Databases, Genetic,
pubmed-meshheading:21044949-Ephrin-A2,
pubmed-meshheading:21044949-Genetic Predisposition to Disease,
pubmed-meshheading:21044949-Genome-Wide Association Study,
pubmed-meshheading:21044949-Genotype,
pubmed-meshheading:21044949-Haplotypes,
pubmed-meshheading:21044949-Hong Kong,
pubmed-meshheading:21044949-Humans,
pubmed-meshheading:21044949-Lupus Erythematosus, Systemic,
pubmed-meshheading:21044949-Polymerase Chain Reaction,
pubmed-meshheading:21044949-Polymorphism, Single Nucleotide,
pubmed-meshheading:21044949-Sequence Analysis, DNA,
pubmed-meshheading:21044949-T-Lymphocytes,
pubmed-meshheading:21044949-Thailand,
pubmed-meshheading:21044949-Transcription Factors
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pubmed:year |
2011
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pubmed:articleTitle |
ELF1 is associated with systemic lupus erythematosus in Asian populations.
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pubmed:affiliation |
Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, LKS Faculty of Medicine,The University of Hong Kong, 21 Sassoon Road, Hong Kong, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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