Source:http://linkedlifedata.com/resource/pubmed/id/21044313
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2010-11-22
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| pubmed:abstractText |
Protein tyrosine phosphatases (PTPs) are important cell signaling regulators with major pathological implications. LYP (also known as PTPN22) is an intracellular enzyme initially found to be predominately expressed in lymphocytes. Importantly, an allelic R620W variant of LYP is strongly associated with multiple autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, type 1 diabetes, and autoimmune thyroid disease.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1471-2199
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
78
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| pubmed:meshHeading |
pubmed-meshheading:21044313-Alternative Splicing,
pubmed-meshheading:21044313-Amino Acid Sequence,
pubmed-meshheading:21044313-Humans,
pubmed-meshheading:21044313-Molecular Sequence Data,
pubmed-meshheading:21044313-Protein Isoforms,
pubmed-meshheading:21044313-Protein Tyrosine Phosphatase, Non-Receptor Type 22,
pubmed-meshheading:21044313-Sequence Alignment
|
| pubmed:year |
2010
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| pubmed:articleTitle |
Identification of a variant form of tyrosine phosphatase LYP.
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| pubmed:affiliation |
Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|