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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-11-2
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pubmed:databankReference |
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pubmed:abstractText |
Experimental infection of malaria-naïve volunteers by the bite of Plasmodium falciparum-infected mosquitoes is a preferred means to test the protective effect of malaria vaccines and drugs. The standard model relies on the bite of five infected mosquitoes to induce malaria. We examined the efficacy of malaria transmission using mosquitoes raised aseptically in compliance with current Good Manufacturing Practices (cGMPs).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
pubmed-author:AdamsMatthewM,
pubmed-author:BillingsleyPeter FPF,
pubmed-author:ChakravartySumanaS,
pubmed-author:EdelmanRobertR,
pubmed-author:HoffmanStephen LSL,
pubmed-author:LaurensMatthewM,
pubmed-author:LoyevskyMarkM,
pubmed-author:LykeKirsten EKE,
pubmed-author:PloweChristopher VCV,
pubmed-author:RichmanAdamA,
pubmed-author:SimB Kim LeeBK
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e13490
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pubmed:meshHeading |
pubmed-meshheading:21042404-Adolescent,
pubmed-meshheading:21042404-Adult,
pubmed-meshheading:21042404-Animals,
pubmed-meshheading:21042404-Anopheles,
pubmed-meshheading:21042404-Female,
pubmed-meshheading:21042404-Humans,
pubmed-meshheading:21042404-Insect Bites and Stings,
pubmed-meshheading:21042404-Malaria, Falciparum,
pubmed-meshheading:21042404-Male,
pubmed-meshheading:21042404-Plasmodium falciparum,
pubmed-meshheading:21042404-Polymerase Chain Reaction
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pubmed:year |
2010
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pubmed:articleTitle |
Plasmodium falciparum malaria challenge by the bite of aseptic Anopheles stephensi mosquitoes: results of a randomized infectivity trial.
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pubmed:affiliation |
Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America. KLyke@medicine.umaryland.edu
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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