| pubmed-article:21041550 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21041550 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:21041550 | lifeskim:mentions | umls-concept:C0814942 | lld:lifeskim |
| pubmed-article:21041550 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:21041550 | lifeskim:mentions | umls-concept:C0266075 | lld:lifeskim |
| pubmed-article:21041550 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:21041550 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:21041550 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:21041550 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21041550 | pubmed:dateCreated | 2010-12-23 | lld:pubmed |
| pubmed-article:21041550 | pubmed:abstractText | Mandibular prognathism is a common dentofacial phenotype with a substantial genetic component; however, few susceptibility loci have been mapped. Ethnicity is a risk factor for mandibular prognathism, and a relatively high prevalence is observed in Asian populations. The hypothesis of this study suggested that a specific locus for mandibular prognathism exists in the Han Chinese population. So, the authors studied a Han Chinese pedigree in which mandibular prognathism was inherited (11 affected, 10 unaffected) in an autosomal dominant pattern. A genomewide linkage scan was performed with the Illumina Linkage-12 DNA Analysis Kit. Multipoint parametric and nonparametric linkage analyses were performed with MERLIN 1.01. A susceptibility locus was identified on chromosome 14q24.3-31.2, with a nonparametric linkage score of 11.341 (empirical P = .020) and a logarithm of the odds score of 2.032 (empirical P = .008). Haplotype analysis refined the candidate locus to a 10.62-cM interval (72.42 to 83.14 cM; 74.57 to 84.66 Mb) between rs1468507 and rs7141857. Within this interval, the candidate functional genes are TGFB3 and LTBP2. In conclusion, the authors detected a suggestive linkage for mandibular prognathism in a Han Chinese pedigree, and this finding can be combined with previous studies to further understand the genetic basis of mandibular prognathism. | lld:pubmed |
| pubmed-article:21041550 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21041550 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21041550 | pubmed:citationSubset | D | lld:pubmed |
| pubmed-article:21041550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21041550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21041550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21041550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21041550 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21041550 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:21041550 | pubmed:issn | 1544-0591 | lld:pubmed |
| pubmed-article:21041550 | pubmed:author | pubmed-author:LUEE | lld:pubmed |
| pubmed-article:21041550 | pubmed:author | pubmed-author:CheaII | lld:pubmed |
| pubmed-article:21041550 | pubmed:author | pubmed-author:LULL | lld:pubmed |
| pubmed-article:21041550 | pubmed:author | pubmed-author:ZhangFF | lld:pubmed |
| pubmed-article:21041550 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21041550 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:21041550 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21041550 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21041550 | pubmed:pagination | 53-7 | lld:pubmed |
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| pubmed-article:21041550 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21041550 | pubmed:articleTitle | The identification of a novel locus for mandibular prognathism in the Han Chinese population. | lld:pubmed |
| pubmed-article:21041550 | pubmed:affiliation | Department of Orthodontics, Dental School, Tongji University, Shanghai, People's Republic of China. | lld:pubmed |
| pubmed-article:21041550 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21041550 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:4053 | entrezgene:pubmed | pubmed-article:21041550 | lld:entrezgene |
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| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21041550 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21041550 | lld:entrezgene |
