Source:http://linkedlifedata.com/resource/pubmed/id/21041550
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-12-23
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| pubmed:abstractText |
Mandibular prognathism is a common dentofacial phenotype with a substantial genetic component; however, few susceptibility loci have been mapped. Ethnicity is a risk factor for mandibular prognathism, and a relatively high prevalence is observed in Asian populations. The hypothesis of this study suggested that a specific locus for mandibular prognathism exists in the Han Chinese population. So, the authors studied a Han Chinese pedigree in which mandibular prognathism was inherited (11 affected, 10 unaffected) in an autosomal dominant pattern. A genomewide linkage scan was performed with the Illumina Linkage-12 DNA Analysis Kit. Multipoint parametric and nonparametric linkage analyses were performed with MERLIN 1.01. A susceptibility locus was identified on chromosome 14q24.3-31.2, with a nonparametric linkage score of 11.341 (empirical P = .020) and a logarithm of the odds score of 2.032 (empirical P = .008). Haplotype analysis refined the candidate locus to a 10.62-cM interval (72.42 to 83.14 cM; 74.57 to 84.66 Mb) between rs1468507 and rs7141857. Within this interval, the candidate functional genes are TGFB3 and LTBP2. In conclusion, the authors detected a suggestive linkage for mandibular prognathism in a Han Chinese pedigree, and this finding can be combined with previous studies to further understand the genetic basis of mandibular prognathism.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
D
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/LTBP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Latent TGF-beta Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TGFB3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta3
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1544-0591
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
90
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
53-7
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| pubmed:meshHeading |
pubmed-meshheading:21041550-Adolescent,
pubmed-meshheading:21041550-Adult,
pubmed-meshheading:21041550-Cephalometry,
pubmed-meshheading:21041550-Child,
pubmed-meshheading:21041550-China,
pubmed-meshheading:21041550-Chromosome Mapping,
pubmed-meshheading:21041550-Chromosomes, Human, Pair 14,
pubmed-meshheading:21041550-Chromosomes, Human, Pair 21,
pubmed-meshheading:21041550-Chromosomes, Human, Pair 4,
pubmed-meshheading:21041550-Ethnic Groups,
pubmed-meshheading:21041550-Female,
pubmed-meshheading:21041550-Genes, Dominant,
pubmed-meshheading:21041550-Genetic Linkage,
pubmed-meshheading:21041550-Genetic Predisposition to Disease,
pubmed-meshheading:21041550-Genotype,
pubmed-meshheading:21041550-Haplotypes,
pubmed-meshheading:21041550-Humans,
pubmed-meshheading:21041550-Latent TGF-beta Binding Proteins,
pubmed-meshheading:21041550-Lod Score,
pubmed-meshheading:21041550-Male,
pubmed-meshheading:21041550-Middle Aged,
pubmed-meshheading:21041550-Pedigree,
pubmed-meshheading:21041550-Phenotype,
pubmed-meshheading:21041550-Prognathism,
pubmed-meshheading:21041550-Transforming Growth Factor beta3,
pubmed-meshheading:21041550-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
The identification of a novel locus for mandibular prognathism in the Han Chinese population.
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| pubmed:affiliation |
Department of Orthodontics, Dental School, Tongji University, Shanghai, People's Republic of China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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