Linked Life Data

21040764

Source:http://linkedlifedata.com/resource/pubmed/id/21040764

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2010-12-27
pubmed:abstractText
The purpose of the present study was to develop a novel, simple and determination-of-electrical-conductivity-based method to trace the gelling process of injectable biodegradable in situ forming organogels after administration. The electrical conductivity of pH 7.4 PBS solution with different amount of N-methyl-2-pyrrolodone (NMP) and drug-free organogel formulation contained 0.6mL NMP were determined at 37 °C, respectively. The electrical conductivity of PBS solution was linearly proportional to the amount of NMP. Organogel contained 0.6 mL NMP in PBS solution showed a descending of electrical conductivity as time runs, while the value of electrical conductivity was almost a constant at 7.58 ms/cm after 110 min, which was nearly equaled to the electrical conductivity of 0.6 mL NMP in PBS solution (7.59 ms/cm). This data indicated that the diffusion of NMP caused the descending of system electrical conductivity and NMP completely diffused from organogel after 110 min, which led to the constant electrical conductivity. Meanwhile, photographs of organogel showed that the gel formed from periphery to center gradually, and totally formed after 110 min. The diffusion terminal point of NMP from organogel could be perfectly anticipated and controlled by this method. Consequently, this electrochemical method had visually simulated the gelling process and located gelling time of organogel in medium solution by measuring variation of electrical conductivity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1873-3476
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
14
pubmed:volume
404
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
176-9
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
A novel, simple method to simulate gelling process of injectable biodegradable in situ forming drug delivery system based on determination of electrical conductivity.
pubmed:affiliation
School of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't