Source:http://linkedlifedata.com/resource/pubmed/id/21040458
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2011-2-22
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| pubmed:abstractText |
Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable developmental disorder characterized by a persistent impairing pattern of inattention and/or hyperactivity-impulsivity. Using families from a genetic isolate, the Paisa population from Colombia, and five independent datasets from four different populations (United States, Germany, Norway and Spain), a highly consistent association was recently reported between ADHD and the latrophilin 3 (LPHN3) gene, a brain-specific member of the LPHN subfamily of G-protein-coupled receptors that is expressed in ADHD-related regions, such as amygdala, caudate nucleus, cerebellum and cerebral cortex. To replicate the association between LPHN3 and ADHD in adults, we undertook a case-control association study in 334 adult patients with ADHD and 334 controls with 43 single nucleotide polymorphisms (SNPs) covering the LPNH3 gene. Single- and multiple-marker analyses showed additional evidence of association between LPHN3 and combined type ADHD in adulthood [P = 0.0019; df = 1; odds ratio (OR) = 1.82 (1.25-2.70) and P = 5.1e-05; df = 1; OR = 2.25 (1.52-3.34), respectively]. These results further support the LPHN3 contribution to combined type ADHD, and specifically to the persistent form of the disorder, and point at this new neuronal pathway as a common susceptibility factor for ADHD throughout the lifespan.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Genetic Markers,
http://linkedlifedata.com/resource/pubmed/chemical/LPHN3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Peptide
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1601-183X
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| pubmed:author |
pubmed-author:Arcos-BurgosMM,
pubmed-author:BayésMM,
pubmed-author:BielsaAA,
pubmed-author:BoschRR,
pubmed-author:CasalJJ,
pubmed-author:CastellanosF XFX,
pubmed-author:CormandBB,
pubmed-author:GastaminzaXX,
pubmed-author:MuenkeMM,
pubmed-author:PalombaUU,
pubmed-author:Ramos-QuirogaJ AJA,
pubmed-author:RibasésMM,
pubmed-author:RicharteVV,
pubmed-author:Sánchez-MoraCC
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| pubmed:copyrightInfo |
© 2010 The Authors. Genes, Brain and Behavior © 2010 Blackwell Publishing Ltd and International Behavioural and Neural Genetics Society.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
10
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
149-57
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| pubmed:meshHeading |
pubmed-meshheading:21040458-Adult,
pubmed-meshheading:21040458-Attention Deficit Disorder with Hyperactivity,
pubmed-meshheading:21040458-Case-Control Studies,
pubmed-meshheading:21040458-DNA,
pubmed-meshheading:21040458-Diagnostic and Statistical Manual of Mental Disorders,
pubmed-meshheading:21040458-Female,
pubmed-meshheading:21040458-Genetic Markers,
pubmed-meshheading:21040458-Genetic Predisposition to Disease,
pubmed-meshheading:21040458-Genotype,
pubmed-meshheading:21040458-Haplotypes,
pubmed-meshheading:21040458-Humans,
pubmed-meshheading:21040458-Linkage Disequilibrium,
pubmed-meshheading:21040458-Male,
pubmed-meshheading:21040458-Neuropsychological Tests,
pubmed-meshheading:21040458-Polymorphism, Single Nucleotide,
pubmed-meshheading:21040458-Quality Control,
pubmed-meshheading:21040458-Receptors, G-Protein-Coupled,
pubmed-meshheading:21040458-Receptors, Peptide,
pubmed-meshheading:21040458-Spain
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| pubmed:year |
2011
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| pubmed:articleTitle |
Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: a replication study.
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| pubmed:affiliation |
Department of Psychiatry, Hospital Universitari Vall d'Hebron, Passeig Vall d'Hebron 119-129, Barcelona, Catalonia, Spain. mribases@ir.vhebron.net
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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