| pubmed-article:21039754 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21039754 | lifeskim:mentions | umls-concept:C1522318 | lld:lifeskim |
| pubmed-article:21039754 | lifeskim:mentions | umls-concept:C0034107 | lld:lifeskim |
| pubmed-article:21039754 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:21039754 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:21039754 | lifeskim:mentions | umls-concept:C0678544 | lld:lifeskim |
| pubmed-article:21039754 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:21039754 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:21039754 | lifeskim:mentions | umls-concept:C0439830 | lld:lifeskim |
| pubmed-article:21039754 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:21039754 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:21039754 | lifeskim:mentions | umls-concept:C1519957 | lld:lifeskim |
| pubmed-article:21039754 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21039754 | pubmed:dateCreated | 2011-1-4 | lld:pubmed |
| pubmed-article:21039754 | pubmed:abstractText | 1. Coronary endothelial function and brachial-ankle pulse wave velocity (baPWV) are independent predictors of cardiovascular events. Thus, in the present study we examined the relationship between baPWV and endothelium-dependent and -independent coronary vasodilatory functions. 2. Sixty-five patients (12 diabetic and 53 non-diabetic) with no significant stenosis of the coronary artery were studied and baPWV determined. After cardiac catheterization, graded doses of bradykinin (BK; 0.2, 0.6 and 2.0 ?g/min), nitroglycerin (NTG; 250 ?g) and papaverine (Pa; 12 mg) were administered into the left anterior descending coronary artery. Coronary blood flow (CBF) was measured using a Doppler flow wire. 3. In the 65 patients, an inverse correlation was found between baPWV and the percentage change in epicardial coronary artery diameter (?%CoD), as well as the percentage change in CBF (?%CBF), following administration of BK (endothelium-dependent vasodilator). Moreover, inverse correlations were found between baPWV and ?%CoD following administration of NTG (endothelium-independent vasodilator) and ?%CBF following administration of Pa (endothelium-independent vasodilator). 4. Multivariate analysis revealed diabetes to be independently and significantly associated with baPWV, BK-induced ?%CBF and ?%CoD and Pa-induced ?%CBF. 5. In conclusion, the results of the present study suggest that increased baPWV is associated with endothelium-dependent and -independent coronary vasodilatory dysfunction. Non-invasive and straightforward baPWV measurement may be useful for the assessment of coronary risk factors, particularly in diabetic patients. | lld:pubmed |
| pubmed-article:21039754 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21039754 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21039754 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21039754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21039754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21039754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21039754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21039754 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21039754 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:21039754 | pubmed:issn | 1440-1681 | lld:pubmed |
| pubmed-article:21039754 | pubmed:author | pubmed-author:MatsumotoTets... | lld:pubmed |
| pubmed-article:21039754 | pubmed:author | pubmed-author:HorieMinoruM | lld:pubmed |
| pubmed-article:21039754 | pubmed:author | pubmed-author:NakaeIchiroI | lld:pubmed |
| pubmed-article:21039754 | pubmed:author | pubmed-author:MitsunamiKeni... | lld:pubmed |
| pubmed-article:21039754 | pubmed:author | pubmed-author:YoshinoTomohi... | lld:pubmed |
| pubmed-article:21039754 | pubmed:copyrightInfo | © 2010 The Authors. Clinical and Experimental Pharmacology and Physiology © 2010 Blackwell Publishing Asia Pty Ltd. | lld:pubmed |
| pubmed-article:21039754 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21039754 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:21039754 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21039754 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21039754 | pubmed:pagination | 34-41 | lld:pubmed |
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| pubmed-article:21039754 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21039754 | pubmed:articleTitle | Association between brachial-ankle pulse wave velocity and endothelium-dependent and -independent coronary vasomotor function. | lld:pubmed |
| pubmed-article:21039754 | pubmed:affiliation | Departments of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta, Otsu, Japan. | lld:pubmed |
| pubmed-article:21039754 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21039754 | pubmed:publicationType | Clinical Trial | lld:pubmed |
