Source:http://linkedlifedata.com/resource/pubmed/id/21039754
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2011-1-4
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pubmed:abstractText |
1. Coronary endothelial function and brachial-ankle pulse wave velocity (baPWV) are independent predictors of cardiovascular events. Thus, in the present study we examined the relationship between baPWV and endothelium-dependent and -independent coronary vasodilatory functions. 2. Sixty-five patients (12 diabetic and 53 non-diabetic) with no significant stenosis of the coronary artery were studied and baPWV determined. After cardiac catheterization, graded doses of bradykinin (BK; 0.2, 0.6 and 2.0 ?g/min), nitroglycerin (NTG; 250 ?g) and papaverine (Pa; 12 mg) were administered into the left anterior descending coronary artery. Coronary blood flow (CBF) was measured using a Doppler flow wire. 3. In the 65 patients, an inverse correlation was found between baPWV and the percentage change in epicardial coronary artery diameter (?%CoD), as well as the percentage change in CBF (?%CBF), following administration of BK (endothelium-dependent vasodilator). Moreover, inverse correlations were found between baPWV and ?%CoD following administration of NTG (endothelium-independent vasodilator) and ?%CBF following administration of Pa (endothelium-independent vasodilator). 4. Multivariate analysis revealed diabetes to be independently and significantly associated with baPWV, BK-induced ?%CBF and ?%CoD and Pa-induced ?%CBF. 5. In conclusion, the results of the present study suggest that increased baPWV is associated with endothelium-dependent and -independent coronary vasodilatory dysfunction. Non-invasive and straightforward baPWV measurement may be useful for the assessment of coronary risk factors, particularly in diabetic patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1440-1681
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pubmed:author | |
pubmed:copyrightInfo |
© 2010 The Authors. Clinical and Experimental Pharmacology and Physiology © 2010 Blackwell Publishing Asia Pty Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
34-41
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pubmed:meshHeading |
pubmed-meshheading:21039754-Adult,
pubmed-meshheading:21039754-Aged,
pubmed-meshheading:21039754-Ankle,
pubmed-meshheading:21039754-Ankle Brachial Index,
pubmed-meshheading:21039754-Blood Flow Velocity,
pubmed-meshheading:21039754-Blood Pressure,
pubmed-meshheading:21039754-Brachial Artery,
pubmed-meshheading:21039754-Bradykinin,
pubmed-meshheading:21039754-Coronary Circulation,
pubmed-meshheading:21039754-Coronary Vessels,
pubmed-meshheading:21039754-Endothelium, Vascular,
pubmed-meshheading:21039754-Female,
pubmed-meshheading:21039754-Humans,
pubmed-meshheading:21039754-Male,
pubmed-meshheading:21039754-Middle Aged,
pubmed-meshheading:21039754-Nitroglycerin,
pubmed-meshheading:21039754-Papaverine,
pubmed-meshheading:21039754-Pulsatile Flow,
pubmed-meshheading:21039754-Vasodilation,
pubmed-meshheading:21039754-Vasodilator Agents
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pubmed:year |
2011
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pubmed:articleTitle |
Association between brachial-ankle pulse wave velocity and endothelium-dependent and -independent coronary vasomotor function.
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pubmed:affiliation |
Departments of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta, Otsu, Japan.
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pubmed:publicationType |
Journal Article,
Clinical Trial
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