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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2011-1-4
pubmed:abstractText
1. Coronary endothelial function and brachial-ankle pulse wave velocity (baPWV) are independent predictors of cardiovascular events. Thus, in the present study we examined the relationship between baPWV and endothelium-dependent and -independent coronary vasodilatory functions. 2. Sixty-five patients (12 diabetic and 53 non-diabetic) with no significant stenosis of the coronary artery were studied and baPWV determined. After cardiac catheterization, graded doses of bradykinin (BK; 0.2, 0.6 and 2.0 ?g/min), nitroglycerin (NTG; 250 ?g) and papaverine (Pa; 12 mg) were administered into the left anterior descending coronary artery. Coronary blood flow (CBF) was measured using a Doppler flow wire. 3. In the 65 patients, an inverse correlation was found between baPWV and the percentage change in epicardial coronary artery diameter (?%CoD), as well as the percentage change in CBF (?%CBF), following administration of BK (endothelium-dependent vasodilator). Moreover, inverse correlations were found between baPWV and ?%CoD following administration of NTG (endothelium-independent vasodilator) and ?%CBF following administration of Pa (endothelium-independent vasodilator). 4. Multivariate analysis revealed diabetes to be independently and significantly associated with baPWV, BK-induced ?%CBF and ?%CoD and Pa-induced ?%CBF. 5. In conclusion, the results of the present study suggest that increased baPWV is associated with endothelium-dependent and -independent coronary vasodilatory dysfunction. Non-invasive and straightforward baPWV measurement may be useful for the assessment of coronary risk factors, particularly in diabetic patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1440-1681
pubmed:author
pubmed:copyrightInfo
© 2010 The Authors. Clinical and Experimental Pharmacology and Physiology © 2010 Blackwell Publishing Asia Pty Ltd.
pubmed:issnType
Electronic
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
34-41
pubmed:meshHeading
pubmed-meshheading:21039754-Adult, pubmed-meshheading:21039754-Aged, pubmed-meshheading:21039754-Ankle, pubmed-meshheading:21039754-Ankle Brachial Index, pubmed-meshheading:21039754-Blood Flow Velocity, pubmed-meshheading:21039754-Blood Pressure, pubmed-meshheading:21039754-Brachial Artery, pubmed-meshheading:21039754-Bradykinin, pubmed-meshheading:21039754-Coronary Circulation, pubmed-meshheading:21039754-Coronary Vessels, pubmed-meshheading:21039754-Endothelium, Vascular, pubmed-meshheading:21039754-Female, pubmed-meshheading:21039754-Humans, pubmed-meshheading:21039754-Male, pubmed-meshheading:21039754-Middle Aged, pubmed-meshheading:21039754-Nitroglycerin, pubmed-meshheading:21039754-Papaverine, pubmed-meshheading:21039754-Pulsatile Flow, pubmed-meshheading:21039754-Vasodilation, pubmed-meshheading:21039754-Vasodilator Agents
pubmed:year
2011
pubmed:articleTitle
Association between brachial-ankle pulse wave velocity and endothelium-dependent and -independent coronary vasomotor function.
pubmed:affiliation
Departments of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta, Otsu, Japan.
pubmed:publicationType
Journal Article, Clinical Trial