Source:http://linkedlifedata.com/resource/pubmed/id/21036892
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2010-11-1
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| pubmed:abstractText |
Rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR) kinase, has attracted interest as a possible prophylactic for post-traumatic stress disorder (PTSD)-associated fear memories. We report here that although rapamycin (40 mg/kg, i.p.) disrupted the consolidation and reconsolidation of fear-potentiated startle paradigm to a shock-paired context, it did not disrupt startle increases to a 4-sec odor cue, even though post-training increases in amygdala mTOR activity were prevented by rapamycin (also 40 mg/kg, i.p.). Thus, while rapamycin may prove useful in retarding the development of some PTSD-associated memories, its relative ineffectiveness against cued fear memories may limit its clinical usefulness.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
|
| pubmed:issn |
1549-5485
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
17
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
577-81
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| pubmed:dateRevised |
2011-5-12
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| pubmed:meshHeading |
pubmed-meshheading:21036892-Analysis of Variance,
pubmed-meshheading:21036892-Animals,
pubmed-meshheading:21036892-Conditioning, Classical,
pubmed-meshheading:21036892-Cues,
pubmed-meshheading:21036892-Electroshock,
pubmed-meshheading:21036892-Extinction, Psychological,
pubmed-meshheading:21036892-Fear,
pubmed-meshheading:21036892-Immunosuppressive Agents,
pubmed-meshheading:21036892-Injections, Intraperitoneal,
pubmed-meshheading:21036892-Male,
pubmed-meshheading:21036892-Memory,
pubmed-meshheading:21036892-Odors,
pubmed-meshheading:21036892-Phosphorylation,
pubmed-meshheading:21036892-Rats,
pubmed-meshheading:21036892-Rats, Sprague-Dawley,
pubmed-meshheading:21036892-Ribosomal Protein S6 Kinases, 70-kDa,
pubmed-meshheading:21036892-Sirolimus,
pubmed-meshheading:21036892-Startle Reaction,
pubmed-meshheading:21036892-Time Factors
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| pubmed:year |
2010
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| pubmed:articleTitle |
Differing effects of systemically administered rapamycin on consolidation and reconsolidation of context vs. cued fear memories.
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| pubmed:affiliation |
Department of Psychiatry and Behavioral Sciences, Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30302, USA. eglover@emory.edu
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|