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rdf:type |
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lifeskim:mentions |
umls-concept:C0012000,
umls-concept:C0018787,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0023981,
umls-concept:C0030705,
umls-concept:C0034656,
umls-concept:C0205210,
umls-concept:C0205360,
umls-concept:C0332161,
umls-concept:C0449438,
umls-concept:C0449829,
umls-concept:C0529793,
umls-concept:C0542341,
umls-concept:C0599724,
umls-concept:C1135191,
umls-concept:C1274040,
umls-concept:C1522565
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pubmed:issue |
1
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pubmed:dateCreated |
2011-1-19
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pubmed:databankReference |
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pubmed:abstractText |
In heart failure (HF), a defective nitric oxide signaling is involved in left ventricular (LV) diastolic abnormalities and remodeling. PDE5 inhibition, by blocking degradation of nitric oxide second-messenger cyclic guanosine monophosphate, might be beneficial. In a cohort of systolic HF patients, we tested the effects of PDE5 inhibition (sildenafil) on LV ejection fraction, diastolic function, cardiac geometry, and clinical status.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1941-3297
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8-17
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pubmed:dateRevised |
2011-10-27
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pubmed:meshHeading |
pubmed-meshheading:21036891-Adult,
pubmed-meshheading:21036891-Aged,
pubmed-meshheading:21036891-Aged, 80 and over,
pubmed-meshheading:21036891-Blood Pressure,
pubmed-meshheading:21036891-Diastole,
pubmed-meshheading:21036891-Double-Blind Method,
pubmed-meshheading:21036891-Exercise Test,
pubmed-meshheading:21036891-Heart Failure, Systolic,
pubmed-meshheading:21036891-Humans,
pubmed-meshheading:21036891-Longitudinal Studies,
pubmed-meshheading:21036891-Male,
pubmed-meshheading:21036891-Middle Aged,
pubmed-meshheading:21036891-Myocardium,
pubmed-meshheading:21036891-Natriuretic Peptide, Brain,
pubmed-meshheading:21036891-Peptide Fragments,
pubmed-meshheading:21036891-Phosphodiesterase 5 Inhibitors,
pubmed-meshheading:21036891-Piperazines,
pubmed-meshheading:21036891-Prospective Studies,
pubmed-meshheading:21036891-Purines,
pubmed-meshheading:21036891-Quality of Life,
pubmed-meshheading:21036891-Sulfones,
pubmed-meshheading:21036891-Ventricular Dysfunction, Left
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pubmed:year |
2011
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pubmed:articleTitle |
PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study.
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pubmed:affiliation |
Cardiopulmonary Unit and Department of Cardiology, University of Milano, San Paolo Hospital, Via A. di Rudinì 8, Milan, Italy. marco.guazzi@unimi.it
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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