21036328

Source:http://linkedlifedata.com/resource/pubmed/id/21036328

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003123, umls-concept:C0314603, umls-concept:C2267227, umls-concept:C2607943, umls-concept:C2926606
pubmed:dateCreated	2010-11-1
pubmed:abstractText	Anorexia nervosa (AN) and bulimia nervosa (BN) are complex disorders associated with disordered eating behavior. Heritability estimates derived from twin and family studies are high, so that substantial genetic influences on the etiology can be assumed for both. As the monoaminergic neurotransmitter systems are involved in eating disorders (EDs), candidate gene studies have centered on related genes; additionally, genes relevant for body weight regulation have been considered as candidates. Unfortunately, this approach has yielded very few positive results; confirmed associations or findings substantiated in meta-analyses are scant. None of these associations can be considered unequivocally validated. Systematic genome-wide approaches have been performed to identify genes with no a priori evidence for their relevance in EDs. Family-based scans revealed linkage peaks in single chromosomal regions for AN and BN. Analyses of candidate genes in one of these regions led to the identification of genetic variants associated with AN. Currently, an international consortium is conducting a genome-wide association study for AN, which will hopefully lead to the identification of the first genome-wide significant markers.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101498165
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:issn	1878-0814
pubmed:author	pubmed-author:HebebrandJohannesJ, pubmed-author:HinneyAnkeA, pubmed-author:ScheragSusannS
pubmed:copyrightInfo	Copyright © 2010 Elsevier Inc. All rights reserved.
pubmed:issnType	Electronic
pubmed:volume	94
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	241-70
pubmed:meshHeading	pubmed-meshheading:21036328-Anorexia, pubmed-meshheading:21036328-Bulimia Nervosa, pubmed-meshheading:21036328-Environment, pubmed-meshheading:21036328-Genome-Wide Association Study, pubmed-meshheading:21036328-Humans, pubmed-meshheading:21036328-Twin Studies as Topic
pubmed:year	2010
pubmed:articleTitle	Genetic findings in anorexia and bulimia nervosa.
pubmed:affiliation	Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg-Essen, Germany.
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't