Linked Life Data

21035921

Source:http://linkedlifedata.com/resource/pubmed/id/21035921

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2010-11-24
pubmed:abstractText
A series of dibenzyl-?-butyrolactones bearing a hydroxyl group at the benzylic position of 3-benzyl group were synthesized as hydrated analogue of isochaihulactone and evaluated against breast cancer human cell lines (MDA-M231, MCF-7 and T47D). The target compounds were synthesized in 7 steps from known lactone; (S)-(+)-?-benzyloxymethyl-?-butyrolactone. The key step was the aldol condensation between (+)-(R)-?-(benzo[d][1,3]dioxol-5-ylmethyl)-?-butyrolactone and substituted benzaldehydes which afforded corresponding ?-hydroxybenzyl butyrolactone analogues. The cytotoxic study of the synthesized compounds against breast cancer human cell lines showed that some of them inhibit breast cancer human cell proliferation with percentage inhibitions over 50% at concentrations less than 50 ?g/mL.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1768-3254
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Masson SAS. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5979-84
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Isochaihulactone analogues: synthesis and anti-proliferative activity of novel dibenzylbutyrolactones.
pubmed:affiliation
Iranian Research Institute of Plant Protection (IRIPP), Shahid Chamran Avenue, Yaman St. No 1; PO.Box:1454, Tehran, Iran.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't