|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0031727,
umls-concept:C0039943,
umls-concept:C0044602,
umls-concept:C0079429,
umls-concept:C0164786,
umls-concept:C0285761,
umls-concept:C0334227,
umls-concept:C0449445,
umls-concept:C0812228,
umls-concept:C1140680,
umls-concept:C1150481,
umls-concept:C1368105,
umls-concept:C1451005,
umls-concept:C1704259,
umls-concept:C1705325,
umls-concept:C1705987,
umls-concept:C1999216
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2010-12-6
|
|
pubmed:abstractText |
Thioridazine, a derivative of phenothiazine, has been reported to have antiproliferative activity on tumor cells. However, the mechanism has not been well defined.
|
|
pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1095-6859
|
|
pubmed:author |
|
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
120
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
121-7
|
|
pubmed:meshHeading |
pubmed-meshheading:21035837-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:21035837-Apoptosis,
pubmed-meshheading:21035837-Cell Growth Processes,
pubmed-meshheading:21035837-Cell Line, Tumor,
pubmed-meshheading:21035837-Cisplatin,
pubmed-meshheading:21035837-Female,
pubmed-meshheading:21035837-G0 Phase,
pubmed-meshheading:21035837-G1 Phase,
pubmed-meshheading:21035837-Gene Expression Profiling,
pubmed-meshheading:21035837-Humans,
pubmed-meshheading:21035837-Ovarian Neoplasms,
pubmed-meshheading:21035837-Paclitaxel,
pubmed-meshheading:21035837-Phosphatidylinositol 3-Kinase,
pubmed-meshheading:21035837-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:21035837-Signal Transduction,
pubmed-meshheading:21035837-Thioridazine
|
|
pubmed:year |
2011
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|
pubmed:articleTitle |
A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells.
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|
pubmed:affiliation |
Division of Gynecologic Cancer Research, Research Institute and Hospital, National Cancer Center, Goyang 410-769, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
