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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2010-11-8
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pubmed:abstractText |
Guided by the inhibitory activities of indole-containing natural products against isocitrate lyase (ICL) from Candida albicans and sortase A (SrtA) from Staphylococcus aureus, a series of compounds structurally analogous to natural products were synthesized. Eight SrtA inhibitors and an ICL inhibitor having higher activities than the natural products were discovered by screening the enzyme inhibitory activities of synthesized compounds. Among the SrtA inhibitors discovered, six exhibited higher activities than p-hydroxymercuribenzoic acid, which suggests that these compounds have great potential as alternative antibacterial agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6882-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21035332-Aminoacyltransferases,
pubmed-meshheading:21035332-Anti-Bacterial Agents,
pubmed-meshheading:21035332-Bacterial Proteins,
pubmed-meshheading:21035332-Biological Agents,
pubmed-meshheading:21035332-Candida albicans,
pubmed-meshheading:21035332-Cysteine Endopeptidases,
pubmed-meshheading:21035332-Drug Evaluation, Preclinical,
pubmed-meshheading:21035332-Enzyme Inhibitors,
pubmed-meshheading:21035332-Indoles,
pubmed-meshheading:21035332-Isocitrate Lyase,
pubmed-meshheading:21035332-Staphylococcus aureus,
pubmed-meshheading:21035332-Structure-Activity Relationship
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pubmed:year |
2010
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pubmed:articleTitle |
Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase.
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pubmed:affiliation |
Marine Natural Products Laboratory, Korea Ocean Research and Development Institute, Ansan, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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