|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006104,
umls-concept:C0031640,
umls-concept:C0032744,
umls-concept:C0073561,
umls-concept:C0086418,
umls-concept:C0233929,
umls-concept:C0542341,
umls-concept:C0599278,
umls-concept:C0936012,
umls-concept:C1524063,
umls-concept:C1698057,
umls-concept:C1704922,
umls-concept:C1708517,
umls-concept:C2603343
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2010-12-21
|
|
pubmed:abstractText |
[(11)C](R)-rolipram provides a measure of the density of phosphodiesterase 4 (PDE4) in brain, an enzyme that metabolizes cAMP. The aims of this study were to perform kinetic modeling of [(11)C](R)-rolipram in healthy humans using an arterial input function and to replace this arterial input in humans with an image-derived input function.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1095-9572
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Published by Elsevier Inc.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
54
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1903-9
|
|
pubmed:meshHeading |
pubmed-meshheading:21034834-Adult,
pubmed-meshheading:21034834-Algorithms,
pubmed-meshheading:21034834-Brain,
pubmed-meshheading:21034834-Cerebral Arteries,
pubmed-meshheading:21034834-Cyclic Nucleotide Phosphodiesterases, Type 4,
pubmed-meshheading:21034834-Electrocardiography,
pubmed-meshheading:21034834-Female,
pubmed-meshheading:21034834-Humans,
pubmed-meshheading:21034834-Image Processing, Computer-Assisted,
pubmed-meshheading:21034834-Least-Squares Analysis,
pubmed-meshheading:21034834-Magnetic Resonance Imaging,
pubmed-meshheading:21034834-Male,
pubmed-meshheading:21034834-Nonlinear Dynamics,
pubmed-meshheading:21034834-Plasma,
pubmed-meshheading:21034834-Positron-Emission Tomography,
pubmed-meshheading:21034834-Radiopharmaceuticals,
pubmed-meshheading:21034834-Reference Standards,
pubmed-meshheading:21034834-Reproducibility of Results,
pubmed-meshheading:21034834-Rolipram
|
|
pubmed:year |
2011
|
|
pubmed:articleTitle |
Kinetic analysis in human brain of [11C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: a retest study and use of an image-derived input function.
|
|
pubmed:affiliation |
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892-2035, USA.
|
|
pubmed:publicationType |
Journal Article
|
