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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0086418,
umls-concept:C0152013,
umls-concept:C0185117,
umls-concept:C0441712,
umls-concept:C0664336,
umls-concept:C1099354,
umls-concept:C1510779,
umls-concept:C2911684
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pubmed:issue |
20
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pubmed:dateCreated |
2010-11-1
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pubmed:abstractText |
Survivin, a member of the inhibitor of apoptosis protein (IAP) family, overexpresses in tumor cells and not expresses in terminally differentiated adult tissues. This study aimed to investigate the effects of survivin-specific siRNA on cell proliferation, apoptosis and chemosensitivity to cisplatin in vitro and in vivo and explore the mechanisms about decreasing expression of survivin in reversing cancer cells resistance to chemotherapeutic drug.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BIRC5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CCND1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin D1,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Apoptosis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Vault Ribonucleoprotein Particles,
http://linkedlifedata.com/resource/pubmed/chemical/major vault protein
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0366-6999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2901-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21034604-Adenocarcinoma,
pubmed-meshheading:21034604-Animals,
pubmed-meshheading:21034604-Apoptosis,
pubmed-meshheading:21034604-Caspase 3,
pubmed-meshheading:21034604-Cell Line, Tumor,
pubmed-meshheading:21034604-Cisplatin,
pubmed-meshheading:21034604-Cyclin D1,
pubmed-meshheading:21034604-Drug Resistance, Neoplasm,
pubmed-meshheading:21034604-Female,
pubmed-meshheading:21034604-Humans,
pubmed-meshheading:21034604-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:21034604-Lung Neoplasms,
pubmed-meshheading:21034604-Male,
pubmed-meshheading:21034604-Mice,
pubmed-meshheading:21034604-Mice, Inbred BALB C,
pubmed-meshheading:21034604-Microtubule-Associated Proteins,
pubmed-meshheading:21034604-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:21034604-RNA, Messenger,
pubmed-meshheading:21034604-RNA, Small Interfering,
pubmed-meshheading:21034604-Vault Ribonucleoprotein Particles
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pubmed:year |
2010
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pubmed:articleTitle |
Inhibition of survivin expression and mechanisms of reversing drug-resistance of human lung adenocarcinoma cells by siRNA.
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pubmed:affiliation |
Department of Medical Oncology, Affiliated Tumor Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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