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pubmed-article:21034549pubmed:abstractTextPDK1 is an essential protein kinase that plays a critical role in mammalian development. Mouse lacking PDK1 leads to multiple abnormalities and embryonic lethality at E9.5. To elucidate the role of PDK1 in the heart, we investigated the cardiac phenotype of mice that lack PDK1 in the heart in different growth periods and the alteration of PDK1 signaling in human failing heart.lld:pubmed
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pubmed-article:21034549pubmed:articleTitlePDK1 plays a critical role in regulating cardiac function in mice and human.lld:pubmed
pubmed-article:21034549pubmed:affiliationDepartment of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.lld:pubmed
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