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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2010-11-1
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pubmed:abstractText |
PDK1 is an essential protein kinase that plays a critical role in mammalian development. Mouse lacking PDK1 leads to multiple abnormalities and embryonic lethality at E9.5. To elucidate the role of PDK1 in the heart, we investigated the cardiac phenotype of mice that lack PDK1 in the heart in different growth periods and the alteration of PDK1 signaling in human failing heart.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0366-6999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2358-63
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pubmed:meshHeading |
pubmed-meshheading:21034549-Adult,
pubmed-meshheading:21034549-Animals,
pubmed-meshheading:21034549-Female,
pubmed-meshheading:21034549-Glycogen Synthase Kinase 3,
pubmed-meshheading:21034549-Heart,
pubmed-meshheading:21034549-Heart Failure,
pubmed-meshheading:21034549-Humans,
pubmed-meshheading:21034549-Male,
pubmed-meshheading:21034549-Mice,
pubmed-meshheading:21034549-Mice, Inbred C57BL,
pubmed-meshheading:21034549-Mice, Knockout,
pubmed-meshheading:21034549-Middle Aged,
pubmed-meshheading:21034549-Myosin Heavy Chains,
pubmed-meshheading:21034549-Protein-Serine-Threonine Kinases,
pubmed-meshheading:21034549-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:21034549-Signal Transduction,
pubmed-meshheading:21034549-Tamoxifen
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pubmed:year |
2010
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pubmed:articleTitle |
PDK1 plays a critical role in regulating cardiac function in mice and human.
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pubmed:affiliation |
Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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