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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-11-22
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pubmed:abstractText |
Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depression who are in a depressed state in comparison with healthy controls. The aim of this study was to examine the distribution volume ratios (DVRs) of SERT and DAT in drug-free and euthymic patients with a history of major depression. Subjects comprised 13 patients with a history of major depression and 26 sex- and age-matched healthy controls. The euthymic state of depression was defined as a score of 7 or less on the Hamilton Depression Rating Scale. The DVRs of SERT and DAT were approximated using SPECT, with [(123)I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [(99m)Tc] TRODAT-1 as the ligands, respectively. There were no significant differences in the DVRs of SERT or DAT between healthy subjects and euthymic patients with a history of major depression; hence, the SERT and DAT DVRs may not therefore be trait markers for patients with major depression, which helps us to understand more about the pathophysiology of depression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0165-1781
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
184
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-61
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pubmed:meshHeading |
pubmed-meshheading:21030217-Adult,
pubmed-meshheading:21030217-Brain,
pubmed-meshheading:21030217-Brain Mapping,
pubmed-meshheading:21030217-Case-Control Studies,
pubmed-meshheading:21030217-Cinanserin,
pubmed-meshheading:21030217-Depressive Disorder, Major,
pubmed-meshheading:21030217-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:21030217-Female,
pubmed-meshheading:21030217-Humans,
pubmed-meshheading:21030217-Male,
pubmed-meshheading:21030217-Middle Aged,
pubmed-meshheading:21030217-Organotechnetium Compounds,
pubmed-meshheading:21030217-Psychiatric Status Rating Scales,
pubmed-meshheading:21030217-Radiopharmaceuticals,
pubmed-meshheading:21030217-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:21030217-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:21030217-Tropanes
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pubmed:year |
2010
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pubmed:articleTitle |
Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression - a dual-isotope SPECT study.
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pubmed:affiliation |
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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